Environmental enrichment-mediated functional improvement after experimental traumatic brain injury is contingent on task-specific neurobehavioral experience
Environmental enrichment-mediated functional improvement after experimental traumatic brain injury is contingent on task-specific neurobehavioral experience
复制标题
DOI：
10.1016/j.neulet.2007.11.042
复制
发表时间：
2008-02-06
影响因子：
2.5
通讯作者：
Kline, Anthony E.
中科院分区：
文献类型：
--
作者：
Hoffman, Ann N.;Malena, Rebecca R.;Kline, Anthony E.
环境浓缩(EE)在促进创伤性脑损伤(TBI)后功能恢复方面优于标准(STD)住房。然而，脑损伤后EE介导的益处是否依赖于神经行为训练期间的丰富暴露尚未阐明。为了解决这个问题，异氟醚麻醉的成年雄性大鼠接受皮质撞击或假损伤，然后被随机分配到早期EE、延迟EE、连续EE或没有EE(即STD条件)。手术后立即启动持续EE或不持续EE，并在研究期间持续。早期EE在手术后立即开始，持续I周，然后在剩余的研究中进行STD生活(每笼2只大鼠)，而延迟EE在STD早期收容后I周开始。分别在伤后第1-5天和14-18天用已建立的运动和认知测试评估功能结果。3周后对CA(1)/CA(3)神经元进行定量。(3)脑损伤+持续脑损伤组与脑损伤+非脑损伤组相比，细胞丢失明显减轻。在接受早期或连续EE的脑损伤组，与接受延迟EE或未接受EE的组相比，束行走更容易。在接受连续或延迟EE的脑损伤组中，认知训练比接受早期EE或不接受EE的组更强。这些数据表明，脑外伤后EE介导的功能改善取决于特定任务的神经行为经验。(C)2007爱思唯尔爱尔兰有限公司。保留所有权利。
Environmental enrichment (EE) is superior to standard (STD) housing in promoting functional recovery after traumatic brain injury (TBI). However, whether the EE-mediated benefits after TBI are dependent on exposure to enrichment during neurobehavioral training has not been elucidated. To address this issue, isoflurane-anesthetized adult male rats received either a cortical impact or sham injury and were then randomly assigned to early EE, delayed EE, continuous EE or no EE (i.e., STD conditions). Continuous EE or no EE was initiated immediately after surgery and continued for the duration of the study. Early EE began directly after surgery, continued for I week, and was then followed by STD living (2 rats per cage) for the remainder of the study, while delayed EE commenced I week after early STD housing. Functional outcome was assessed with established motor and cognitive tests on post-injury days 1-5 and 14-18, respectively. CA(1)/CA(3) neurons were quantified at 3 weeks. CA(3) cell loss was significantly attenuated in the TBI +continuous EE group versus the TBI + no EE group. Beam-walking was facilitated in the TBI groups that received either early or continuous EE versus those receiving delayed or no EE. Cognitive training was enhanced in the TBI groups that received continuous or delayed EE versus the early EE or no EE groups. These data suggest that EE-mediated functional improvement after TBI is contingent on task-specific neurobehavioral experience. (c) 2007 Elsevier Ireland Ltd. All rights reserved.