Effect of ursodeoxycholic acid and chenodeoxycholic acid on cholesterol and bile acid metabolism.
Effect of ursodeoxycholic acid and chenodeoxycholic acid on cholesterol and bile acid metabolism.
复制标题
熊去氧胆酸和鹅去氧胆酸对胆固醇和胆汁酸代谢的影响。
DOI：
10.1016/0016-5085(86)90708-0
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发表时间：
1986
期刊：
影响因子：
29.4
通讯作者：
Shefer,S
中科院分区：
文献类型：
--
作者：
Tint,GS;Salen,G;Shefer,S
口服UDCA可显著减少胆汁中胆固醇的分泌。在UDCA治疗期间，胆固醇的相对和绝对吸收减少，可能通过适度促进胆汁酸合成和抑制胆固醇生成来维持胆固醇平衡。UDCA在胆汁中的比例受到UDCA不能抑制胆固醇合成胆汁酸的限制，以及肠道细菌将UDCA转化为CDCA的作用。
Orally administered UDCA dramatically reduces the secretion of cholesterol into the bile. During UDCA therapy cholesterol balance is maintained by a reduction in both the relative and absolute absorption of cholesterol and, perhaps, by a combined moderate enhancement of bile acid synthesis and a suppression of cholesterol production.The percentage of UDCA in the bile is limited by the inability of UDCA to suppress bile acid synthesis from cholesterol and by the conversion of UDCA to CDCA by the intestinal bacteria.