Comparative study of tissue reactions to calcium phosphate ceramics among cancellous, cortical, and medullar bone sites in rabbits.
Comparative study of tissue reactions to calcium phosphate ceramics among cancellous, cortical, and medullar bone sites in rabbits.
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DOI：
10.1002/(sici)1097-4636(19981205)42:3
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发表时间：
1998-12
期刊：
影响因子：
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通讯作者：
Jianxi Lu;A. Gallur;B. Flautre;Karine Anselme;M. Descamps;B. Thierry;P. Hardouin
中科院分区：
文献类型：
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作者：
Jianxi Lu;A. Gallur;B. Flautre;Karine Anselme;M. Descamps;B. Thierry;P. Hardouin
为了了解植入部位对骨生物材料评价的影响，我们将HA和β-TCP陶瓷圆柱体植入兔股骨干和髁突。植入后3、8、12和24周，对未脱钙样本进行组织学研究和组织形态计量学。我们的结果表明，空腔（p 80%）和松质骨部位（SBH 0.05）的自发性骨愈合存在显著差异。骨髓组织呈现的异物反应比其他骨组织更可靠、更敏感、更持久。因此，由于成骨和生物降解活性的平衡，松质骨部位是评价生物材料生物功能性的良好部位，但骨髓组织似乎更适合测试材料的体内生物相容性。
In order to understand the influence of the implantation site on bone biomaterial evaluation, we implanted cylinders of HA and beta-TCP ceramics in the femoral diaphysis and condyle of rabbits. After 3, 8, 12, and 24 weeks of implantation, histological investigation and histomorphometry were performed on undecalcified samples. Our results show that spontaneous bone healing in the empty cavities is significantly different (p 80%) and cancellous bone sites (SBH 0.05). The marrow tissue presents a foreign-body reaction more reliable, sensitive, and durable than other bone tissues. Therefore, the cancellous bone site is a good site for evaluation of the biofunctionality of biomaterials because of the equilibrium of the osteogenesis and the biodegradation activities, but marrow tissue seems to be better for testing material biocompatibility in vivo.