The receptor for the cytotoxic ligand TRAIL
The receptor for the cytotoxic ligand TRAIL
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DOI：
10.1126/science.276.5309.111
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发表时间：
1997-04-04
期刊：
影响因子：
56.9
通讯作者：
Dixit, VM
中科院分区：
文献类型：
--
作者：
Pan, GH;ORourke, K;Dixit, VM
TRAIL（也称为Apo-2L）是肿瘤坏死因子（TNF）配体家族的成员，其在多种转化细胞系中快速诱导凋亡。TRAIL的人受体被发现是TNF受体家族的一个未描述的成员（命名为死亡受体-4，DR 4），其含有能够参与细胞自杀装置的细胞质“死亡结构域”，但在所研究的系统中不参与核因子κ B途径。与Fas、TNFR-1和DR 3不同，DR 4不能使用FADD来传递死亡信号，这表明使用了不同的近端信号传导机制。因此，DR 4-TRAIL轴定义了另一个参与调节细胞自杀和组织稳态的受体-配体对。
TRAIL (also known as Apo-2L) is a member of the tumor necrosis factor (TNF) ligand family that rapidly induces apoptosis in a variety of transformed cell lines. The human receptor for TRAIL was found to be an undescribed member of the TNF-receptor family (designated death receptor-4, DR4) that contains a cytoplasmic ''death domain'' capable of engaging the cell suicide apparatus but not the nuclear factor kappa B pathway in the system studied. Unlike Fas, TNFR-1, and DR3, DR4 could not use FADD to transmit the death signal, suggesting the use of distinct proximal signaling machinery. Thus, the DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis.