A well-known potassium channel plays a critical role in lysosomes.
A well-known potassium channel plays a critical role in lysosomes.
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DOI：
10.1083/jcb.201704017
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发表时间：
2017-06-05
期刊：
影响因子：
--
通讯作者：
Zhu MX
中科院分区：
文献类型：
--
作者：
Zhu MX
Zhu讨论了Wang等人关于细胞器离子转运蛋白的工作，描述了溶酶体电压敏感性Ca2+激活的K+通道的重要性。全内溶酶体膜片钳技术为识别和表征这些酸性细胞器的关键通道提供了新的机会。在这个问题上（Wang et al.，2017. J. Cell Biol. https：//doi.org/10.1083/jcb.201612123），大电导钙激活钾通道作用的确定带来了关于调节溶酶体膜电位和功能的新思维。
Zhu discusses work on organeller ion transporters from Wang et al. describing the importance of a lysosomal voltage-sensitive Ca2+-activated K+ channel. Whole-endolysosome patch clamping presents new opportunities to identify and characterize channels pivotal for these acidic organelles. In this issue (Wang et al., 2017. J. Cell Biol. https://doi.org/10.1083/jcb.201612123), the identification of a role for the large conductance calcium-activated potassium channel brings new thinking about regulation of lysosome membrane potential and function.