The Phytophthora Genome Initiative Database: informatics and analysis for distributed pathogenomic research
The Phytophthora Genome Initiative Database: informatics and analysis for distributed pathogenomic research
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DOI：
10.1093/nar/28.1.87
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发表时间：
2000-01-01
影响因子：
14.9
通讯作者：
Sobral, B
中科院分区：
文献类型：
--
作者：
Waugh, M;Hraber, P;Sobral, B
Phytophthora Genome Initiative（PGI）伊萨一个分布式合作项目，旨在研究一组特别具有破坏性的植物病原卵菌的基因组和进化，目的是了解感染和抗性机制，NCGR为合作提供信息学支持以及集中的数据库，在项目的试点阶段，几个研究者制备了致病疫霉和大豆疫霉EST和大豆疫霉BAC文库，并将它们送到另一个实验室进行测序。将来自测序反应的数据转移到NCGR进行分析和处理。分析流水线通过执行简单分析（即，矢量去除和相似性搜索），这些数据被存储并且可以由研究者使用网络浏览器来检索。在这里，我们描述了数据库和访问工具，提供了一个概述，其中的数据和概述未来的计划，这种资源提供了一个独特的机会，分布式的，合作研究的属，从相对较少的序列数据。结果可能会导致洞察如何更好地控制这些病原体。可通过数据库访问超链接访问PGI的主页：http：//www.ncgr.org/pgi。
The Phytophthora Genome Initiative (PGI) isa distributed collaboration to study the genome and evolution of a particularly destructive group of plant pathogenic oomycete, with the goal of understanding the mechanisms of infection and resistance, NCGR provides informatics support for the collaboration as well as a centralized data repository, In the pilot phase of the project, several investigators prepared Phytophthora infestans and Phytophthora sojae EST and Phytophthora sojae BAC libraries and sent them to another laboratory for sequencing. Data from sequencing reactions were transferred to NCGR for analysis and curation. An analysis pipeline transforms raw-data by performing simple analyses (i.e., vector removal and similarity searching) that are stored and dan be retrieved by investigators using a web browser. Here we describe the database and access tools, provide an overview of the data therein and outline future plans, This resource has provided a unique opportunity for the distributed, collaborative study of a genus from which relatively little sequence data are available. Results may lead to insight into how better to control these pathogens. The homepage of PGI can be accessed at http:www.ncgr.org/pgi, with database access through the database access hyperlink.