EFFECT OF PERIODONTAL TREATMENTS ON SERUM IGG ANTIBODY-TITERS AGAINST PERIODONTOPATHIC BACTERIA
EFFECT OF PERIODONTAL TREATMENTS ON SERUM IGG ANTIBODY-TITERS AGAINST PERIODONTOPATHIC BACTERIA
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DOI：
10.1111/j.1600-051x.1995.tb00798.x
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发表时间：
1995-07-01
影响因子：
6.7
通讯作者：
ISHIKAWA, I
中科院分区：
文献类型：
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作者：
HORIBE, M;WATANABE, H;ISHIKAWA, I
检测牙周炎患者初诊时及牙周病治疗后7种致病菌的血清IgG抗体滴度，以探讨影响血清IgG抗体滴度变化的因素。20例成人快速进展性牙周炎患者，男10例，女10例，年龄23 ~ 61岁。Ah患者接受了初步准备，其中大多数还接受了外科手术。治疗后，平均探测袋深度从3.72毫米下降到1.56毫米。血清样本收集患者在初始和最终检查。通过酶联免疫吸附测定法测定针对牙龈卟啉单胞菌FDC 381、中间普雷沃氏菌ATCC 25611、洛氏普雷沃氏菌ATCC 15930、具核梭杆菌具核亚种ATCC 25586、伴放线放线杆菌FDC Y 4、腐蚀艾肯氏菌FDC 1073和赭色二氧化碳噬菌体M 12的超声处理抗原的血清IgG抗体滴度。与治疗前水平相比，治疗后对牙龈卟啉单胞菌和中间型卟啉单胞菌的平均抗体滴度显著降低。特别是牙龈卟啉单胞菌抗体滴度在所有检查的患者中均下降。牙龈卟啉单胞菌抗体滴度的下降与牙周手术的患牙数、治疗时间有显著相关性;中间卟啉单胞菌抗体滴度的下降与拔牙的患牙数也有显著相关性。结果提示，牙龈卟啉单胞菌和中间型卟啉单胞菌血清IgG滴度的变化与龈下菌斑中病原菌的抑制有关。
Serum IgG antibody titers to 7 periodontopathic bacteria in periodontitis patients were measured at the Ist visit and after various periodontal treatments with clinically successful improvement, in order to evaluate what kind of factors are associated with changes of serum antibody titers. 20 patients (10 male and 10 female from 23 to 61 years old) with adult, rapidly progressive periodontitis were enrolled in this study. Ah patients received initial preparation and most of them also underwent surgical procedure. After the treatments, the mean probing pocket depths decreased from 3.72 mm to 1.56 mm. Serum samples were collected from patients at the initial and final examinations. Serum IgG antibody titers against sonicated antigens of Porphyromonas gingivalis FDC 381, Prevotella intermedia ATCC 25611, Prevotella loescheii ATCC 15930, Fusobacterium nucleatum subspecies nucleatum ATCC 25586, Actinobacillus actinomycetemcomitans FDC Y4, Eikenella corrodens FDC 1073 and Capnocytophaga ochracea # M 12 were determined by enzyme-linked immunosorbent assay. The mean antibody titers to P. gingivalis and P. intermedia decreased significantly after the treatment as compared to their pretreatment levels. The antibody titer to P. gingivalis especially, decreased in all of the patients examined. A significant relationship was found between the decreased antibody titer to P. gingivalis and the number of teeth which received periodontal surgery, as well as treatment length, and the relationship between the decreased antibody titer to P. intermedia and the number of extracted teeth was also significant. These results suggest that the changes of serum IgG titers against P. gingivalis and P. intermedia are related to the suppression of such pathogens in subgingival plaque.