Changes in blood alcohol levels as a function of alcohol concentration and repeated alcohol exposure in adult female rats: potential risk factors for alcohol-induced fetal brain injury.
Changes in blood alcohol levels as a function of alcohol concentration and repeated alcohol exposure in adult female rats: potential risk factors for alcohol-induced fetal brain injury.
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成年雌性大鼠血液中酒精浓度随酒精浓度和反复酒精暴露的变化：酒精诱发胎儿脑损伤的潜在危险因素。
DOI：
10.1111/j.1530-0277.1995.tb00968.x
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
West,JR
中科院分区：
文献类型：
--
作者：
Maier,SE;Strittmatter,MA;Chen,WJ;West,JR
胎儿酒精综合征和酒精相关的出生缺陷是母亲在怀孕期间大量饮酒的结果。后代表现出的缺陷程度总是由几个可能导致血液酒精浓度（BAC）高峰的风险因素引起的，如饮酒的持续时间、时间或模式。此外，饮用饮料的酒精含量可能在决定后代发育后果方面发挥作用。由于较高的BAC与出生后早期脑损伤的风险和严重程度呈正相关，因此最初重要的是确定BAC如何受到酒精浓度的影响，以及这种影响是否在重复酒精治疗中保持不变。雌性Sprague道利大鼠组每天接受5 g/kg酒精胃内插管，浓度为45%（v/v）、30%（v/v）、22.5%（v/v）或15%（v/v），持续18天。在给药第3、8、13和18天插管后不同时间采集血样，并通过顶空气相色谱法进行分析。多变量分析的峰值BAC，平均BAC，并达到峰值BAC的时间揭示了一些值得注意的结果。首先，与其他浓度组相比，45%组的峰值BAC和平均BAC显著较低，而该组达到峰值BAC所需的时间也比其他三个组长。第二，BAC峰值和平均BAC在治疗的最后一天高于任何其他治疗日。这些结果表明，酒精浓度和重复酒精暴露可影响BAC，因此，是评估酒精诱导的胎儿脑损伤时需要考虑的重要风险因素。
Fetal alcohol syndrome and alcohol‐related birth defects are the result of heavy maternal alcohol consumption during gestation. The magnitude of deficit manifested by the offspring is invariably a consequence of several risk factors that may result in high peak blood alcohol concentrations (BACs), such as the duration, timing, or pattern of alcohol consumption. In addition, the alcohol content of the consumed beverage may play a role in determining offspring developmental consequences. Because higher BACs are positively correlated with risk and severity of brain injury early in postnatal lie, initially it was important to determine how BAC is influenced by alcohol concentration and whether that influence is constant over repeated alcohol treatments. Groups of female Sprague‐Dawley rats received daily intragastric intubations of 5 g/kg alcohol in one of several concentrations: 45% (v/v), 30% (v/v), 22.5% (v/v), or 15% (v/v) for a duration of 18 consecutive days. Blood samples were taken at various times postintubation on days 3,8,13, and 18 of treatment, and analyzed by headspace gas chromatography. Multivariate analyses of peak BAC, average BAC, and time to reach peak BAC revealed some noteworthy results. First, peak BAC and average BAC were significantly lower in the 45% group, compared with the other concentration groups, whereas this group also took a longer time to reach peak BAC than the other three groups. Second, peak BAC and averege BAC were higher on the last day of treatment than any of the other treatment days. These results suggest that alcohol concentration and repeated alcohol exposure can influence BAC and, as such, are important risk factors to be considered in the appraisal of alcohol‐induced fetal brain injuries.