The Influence of the microbiome on the innate immune microenvironment of solid tumors.
The Influence of the microbiome on the innate immune microenvironment of solid tumors.
复制标题
微生物组对实体瘤先天免疫微环境的影响。
DOI：
10.1016/j.neo.2023.100878
复制
发表时间：
2023-03
期刊：
影响因子：
4.8
通讯作者：
Thomas, Ryan M.
中科院分区：
文献类型：
--
作者：
Charles, Angel;Thomas, Ryan M.
尽管医学和外科疗法取得了许多进步，癌症仍然是死亡的主要原因。近几十年来，对具有更大疗效和副作用降低的新型治疗策略的调查，导致对癌症中微生物组与免疫系统之间的关系有了更深入的了解。免疫系统检测和杀死癌症的能力现在被认为受宿主的微生物生态系统的影响很大。尽管这些研究大多数以及当前使用免疫治疗剂的侧重于适应性免疫系统，但这最大程度地降低了先天免疫系统对癌症监测的影响及其对宿主微生物组的调节。在这篇综述中，将在单个先天免疫细胞的背景下讨论微生物组对肿瘤微环境中先天免疫细胞的已知影响。当前和需要的调查领域将突出该领域及其对固体恶性肿瘤临床治疗的潜在影响。
Cancer remains a leading cause of death despite many advances in medical and surgical therapy. In recent decades, the investigation for novel therapeutic strategies with greater efficacy and reduced side effects has led to a deeper understanding of the relationship between the microbiome and the immune system in the context of cancer. The ability of the immune system to detect and kill cancer is now recognized to be greatly influenced by the microbial ecosystem of the host. While most of these studies, as well as currently used immunotherapeutics, focus on the adaptive immune system, this minimizes the impact of the innate immune system in cancer surveillance and its regulation by the host microbiome. In this review, known influences of the microbiome on the innate immune cells in the tumor microenvironment will be discussed in the context of individual innate immune cells. Current and needed areas of investigation will highlight the field and its potential impact in the clinical treatment of solid malignancies.
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