The transcriptional program in the response of human fibroblasts to serum
The transcriptional program in the response of human fibroblasts to serum
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DOI：
10.1126/science.283.5398.83
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发表时间：
1999-01-01
期刊：
影响因子：
56.9
通讯作者：
Brown, PO
中科院分区：
文献类型：
--
作者：
Iyer, VR;Eisen, MB;Brown, PO
用代表约8600个不同人类基因的互补DNA微阵列探索了人类细胞的模型生理反应（成纤维细胞对血清的反应）期间基因表达的时间程序。在这个程序中，基因可以根据其表达的时间模式聚类成组。转录程序的许多特征似乎与伤口修复的生理学有关，这表明成纤维细胞在这种复杂的多细胞反应中发挥的作用比以前认识到的更大、更丰富。
The temporal program of gene expression during a model physiological response of human cells, the response of fibroblasts to serum, was explored with a complementary DNA microarray representing about 8600 different human genes. Genes could be clustered into groups on the basis of their temporal patterns of expression in this program. Many features of the transcriptional program appeared to be related to the physiology of wound repair, suggesting that fibroblasts play a larger and richer role in this complex multicellular response than had previously been appreciated.