Subsequent pregnancy affects morbidity of previous child
Subsequent pregnancy affects morbidity of previous child
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随后的怀孕会影响前一个孩子的发病率
DOI：
10.1017/s002193200002304x
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发表时间：
1995
影响因子：
1.5
通讯作者：
S. Bergström
中科院分区：
文献类型：
--
作者：
E. Bøhler;S. Bergström
一项对不丹农村113名儿童的前瞻性研究记录了他们的发病率、体重和母亲随后的怀孕情况，在儿童出生后的前3年里，每月记录32个月。母亲生育间隔为18-30个月的儿童在随后怀孕期间的腹泻发生率比母亲未怀孕的匹配队列高50% （p= 0.02）。合计月龄计算的腹泻相对危险度为1.51。母亲怀孕的孩子患皮肤感染的几率也更高。终止母乳喂养时母亲怀孕的儿童在断奶前后腹泻发生率增加（p= 0.01）。同年龄未怀孕母亲断奶的儿童发病率没有增加。这项研究首次将观察到的儿童发病率与母亲随后怀孕的发生直接联系起来，并提供了证据，证明随后中等短的生育间隔与研究儿童发病率同时增加之间存在因果关系。
Summary A prospective study of 113 children in rural Bhutan registered their morbidity and weight and their mothers' subsequent pregnancies, monthly for 32 months during the children's first 3 years of life. Children whose mothers had a subsequent birth interval of 18–30 months had an incidence of diarrhoea during the subsequent pregnancy 50% higher than their matched cohort whose mothers did not become pregnant (p=0·02). The relative risk for diarrhoea calculated from pooled child months was 1·51. Children whose mothers became pregnant also tended to have a higher incidence of skin infections. Children, whose mothers were pregnant when they terminated breastfeeding, experienced an increased incidence of diarrhoea around weaning (p=0·01). Children weaned at the same age from non-pregnant mothers did not show increased morbidity. This study, for the first time, relates observations of children's morbidity directly in time to the occurrence of the mother's subsequent pregnancy, and provides evidence of a causal relationship between a moderately short subsequent birth interval and a concurrent increase in morbidity for the study child.