The mutation rate and cancer
The mutation rate and cancer
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DOI：
10.1073/pnas.93.25.14800
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发表时间：
1996-12-10
影响因子：
11.1
通讯作者：
Bodmer, WF
中科院分区：
文献类型：
--
作者：
Tomlinson, IPM;Novelli, MR;Bodmer, WF
选择有利的突变是肿瘤发生的基础。因此，肿瘤的生长是一种在体细胞水平上的进化形式，其中种群由肿瘤内的单个细胞组成，肿瘤发生的模型考虑了突变和选择的相对重要性，我们表明在肿瘤的生长中，选择比增加突变率更重要。有些癌症可能会获得一种“突变体表型”。可能会导致更快的生长，但突变表型不是致癌所必需的。
The selection of advantageous mutations underlies tumorigenesis. The growth of a tumor is therefore a form of evolution at the somatic level, in which the population is comprised of individual cells within the tumor, Models of tumorigenesis have considered the relative importance of mutation and selection, We show that selection is more important than an increased mutation rate in the growth of a tumor. Some cancers may acquire a ''mutator phenotype.'' probably leading to faster growth, but mutator phenotypes are not necessary for carcinogenesis.