Acetazolamide teratogenesis: association of maternal respiratory acidosis and ectrodactyly in C57BL/6J mice.
Acetazolamide teratogenesis: association of maternal respiratory acidosis and ectrodactyly in C57BL/6J mice.
复制标题
乙酰唑胺致畸：C57BL/6J 小鼠母体呼吸性酸中毒与外指畸形的关联。
DOI：
10.1002/tera.1420300206
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
ScottJr,WJ
中科院分区：
文献类型：
--
作者：
Weaver,TE;ScottJr,WJ
C57 BL/6 J小鼠在妊娠关键期暴露于CO2导致后代主要为右侧、轴后、前肢缺指。CO2所致肢体畸形的发生率和严重程度与吸入CO2的浓度、暴露时胚胎的发育年龄和暴露时间有关。乙酰唑胺处理的C57 BL/6 J小鼠的后代也显示出这种高度特异性的缺指畸形（绿色等人，'73）。由于该药物已被证明可升高组织CO2张力（Mithoefer和Davis，'58），因此乙酰唑胺的致畸作用可能与诱导高碳酸血症的胚胎环境有关。
Exposure of C57BL/6J mice to CO 2 during a critical period of gestation results in predominatly right-sided, postaxial, forelimb ectrodactyly in the offspring. The incidence and severity of CO 2–induced limb malformations has been shown to be dependent on the concentration of inspired CO 2, the developmental age of the embryo at exposure and the duration of CO 2 exposure. Offspring of acetazolamide-treated C57BL/6J mice also display this highly specific form of ectrodactyly (Green et al.,'73). Since the drug has been shown to elevate tissue CO 2 tension (Mithoefer and Davis,'58), the teratogenic effect of acetazolamide may be related to induction of a hypercapnic embryonic environment.