Impact of Injury Location and Severity on Posttraumatic Epilepsy in the Rat: Role of Frontal Neocortex
Impact of Injury Location and Severity on Posttraumatic Epilepsy in the Rat: Role of Frontal Neocortex
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DOI：
10.1093/cercor/bhq218
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发表时间：
2011-07-01
期刊：
影响因子：
3.7
通讯作者：
D'Ambrosio, Raimondo
中科院分区：
文献类型：
--
作者：
Curia, Giulia;Levitt, Michael;D'Ambrosio, Raimondo
人类创伤后癫痫（PTE）具有高度异质性，从轻度缓解型到进行性致残型。 PTE 导致简单部分性、复杂性部分性和继发性全身性癫痫发作，其持续时间和症状多种多样。 PTE 变异被认为取决于头部损伤的异质性以及患者的年龄、性别和遗传背景。为了更好地了解这些因素的作用，我们通过视频皮层电图检查了青春期雄性 Sprague-Dawley 大鼠校准流体冲击损伤 (FPI) 引起的癫痫发作。我们发现 PTE 的发生率以及慢性癫痫发作的频率和严重程度取决于 FPI 的位置和严重程度。额叶新皮质比顶叶和枕叶更容易发生癫痫，部分性癫痫发作更早、持续时间更长、更频繁。无论损伤参数如何，大多数动物都会出现突出的边缘焦点。值得注意的是，即使仔细控制损伤参数，包括类型、严重程度和位置、创伤后呼吸暂停的持续时间以及远交大鼠的年龄和性别，受试者之间的癫痫发作频率、持续时间和进展速度也存在很大差异，这表明其他因素，可能是受试者的遗传背景和生理状态，在确定 PTE 的特征方面发挥着关键作用。
Human posttraumatic epilepsy (PTE) is highly heterogeneous, ranging from mild remitting to progressive disabling forms. PTE results in simple partial, complex partial, and secondarily generalized seizures with a wide spectrum of durations and semiologies. PTE variability is thought to depend on the heterogeneity of head injury and patient's age, gender, and genetic background. To better understand the role of these factors, we investigated the seizures resulting from calibrated fluid percussion injury (FPI) to adolescent male Sprague-Dawley rats with video electrocorticography. We show that PTE incidence and the frequency and severity of chronic seizures depend on the location and severity of FPI. The frontal neocortex was more prone to epileptogenesis than the parietal and occipital, generating earlier, longer, and more frequent partial seizures. A prominent limbic focus developed in most animals, regardless of parameters of injury. Remarkably, even with carefully controlled injury parameters, including type, severity, and location, the duration of posttraumatic apnea and the age and gender of outbred rats, there was great subject-to-subject variability in frequency, duration, and rate of progression of seizures, indicating that other factors, likely the subjects' genetic background and physiological states, have critical roles in determining the characteristics of PTE.