NONINVASIVE, INFRARED MONITORING OF CEREBRAL AND MYOCARDIAL OXYGEN SUFFICIENCY AND CIRCULATORY PARAMETERS
NONINVASIVE, INFRARED MONITORING OF CEREBRAL AND MYOCARDIAL OXYGEN SUFFICIENCY AND CIRCULATORY PARAMETERS
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DOI：
10.1126/science.929199
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发表时间：
1977-01-01
期刊：
影响因子：
56.9
通讯作者：
JOBSIS, FF
中科院分区：
文献类型：
--
作者：
JOBSIS, FF
生物材料在光谱近红外区域相对良好的透明度允许足够的光子传输通过原位器官以监测细胞事件。通过红外透照对暴露的猫心脏和头颅大脑进行观察，无需进行手术干预，结果表明，可以有效、连续地记录细胞色素 a、a3 的 O2 充足度、功能、组织血容量的变化以及平均 Hb-oxyHb 平衡，以用于研究和临床目的。与血红素a3相关的Cu原子对缺氧没有反应，在含氧量正常的条件下可能会被还原；血红素-a Cu 至少部分可还原。
The relatively good transparency of biological materials in the near IR region of the spectrum permits sufficient photon transmission through organs in situ for the monitoring of cellular events. Observations by IR transillumination in the exposed cat heart and in the brain in cephalo without surgical intervention show that O2 sufficiency for cytochrome a,a3, function, changes in tissue blood volume, and the average Hb-oxyHb equilibrium can be recorded effectively and in continuous fashion for research and clinical purposes. The Cu atom associated with heme a3 did not respond to anoxia and may be reduced under normoxic conditions; the heme-a Cu was at least partially reducible.