Neurohumoral Control of Blood Vessels: Some Future Directions
Neurohumoral Control of Blood Vessels: Some Future Directions
复制标题
血管的神经体液控制：未来的一些方向
DOI：
--
复制
发表时间：
1985
影响因子：
3
通讯作者：
G. Burnstock
中科院分区：
文献类型：
--
作者：
G. Burnstock
最近发现的血管神经因子控制机制，涉及各种各样的神经体液因子，连接前和连接后的神经调节，以及共传递，使该领域在新的方向发展。本文概述了其中的一些，包括：不同类型的血管周围神经的模式和密度的定量方法的发展;嘌呤核苷酸和核苷对血管平滑肌和/或内皮细胞的有效作用的探索，特别是与治疗潜力的药物的开发有关;扩大对某些交感神经血管周围神经ATP和去甲肾上腺素以及某些副交感神经VIP和乙酰胆碱共反式释放的调节意义的研究;血管中单胺、肽和嘌呤受体的放射自显影定位;对循环的“轴突反射”控制和P物质的作用进行更广泛的研究;研究不同血管周围神经类型的发育、衰老和再生，以及一些神经体液因子的长期“营养”作用。最后，研究疾病中和慢性药物暴露后血管神经体液控制异常的时机已经成熟。
The recent discoveries of vascular neuroef-fector control mechanisms, involving a wide variety of neurohumoral agents, pre- and postjunctional neuromod-ulation, and cotransmission, leave the field poised for growth in new directions. Some of these are outlined in this article, including: the development of methods for quantitation of the pattern and density of different types of perivascular nerves; exploration of the potent actions of purine nucleotides and nucleosides on vascular smooth muscle and/or endothelial cells, particularly in relation to the development of drugs of therapeutic potential; expansion of studies of the regulatory implications of cotrans-mitter release of ATP together with noradrenaline from some sympathetic perivascular nerves and of VIP together with acetylcholine from some parasympathetic nerves; autoradiographic localization of receptors for monoamines, peptides of and purines in blood vessels; wider studies of “axon reflex” control of the circulation and of the roles of substance P; investigation of development, aging, and regeneration of different perivascular nerve types, and the long-term “trophic” actions of some neurohumoral agents. Lastly, the time is ripe to study abnormalities in neurohumoral control of vessels in disease and after chronic exposure to drugs.