Chinese Medicinal Leech: Ethnopharmacology, Phytochemistry, and Pharmacological Activities.
Chinese Medicinal Leech: Ethnopharmacology, Phytochemistry, and Pharmacological Activities.
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DOI：
10.1155/2016/7895935
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Gao HM
中科院分区：
文献类型：
--
作者：
Dong H;Ren JX;Wang JJ;Ding LS;Zhao JJ;Liu SY;Gao HM
水蛭是一种重要的中药，对脑出血及其他血栓相关疾病具有多种治疗作用。植物化学研究表明，从3种动物来源的水栀中分离出51个化合物，包括蝶啶类、磷脂酰胆碱类、鞘糖脂类、甾醇类以及部分活性肽类化合物。水蛭具有抗凝血、抗血栓、抗动脉粥样硬化、抗血小板聚集、抗肿瘤、抗炎、改善血液流变学、抗脑缺血再灌注损伤等药理作用。然而，基于水之传统用途的一些重要问题仍然不清楚。本文综述了水蛭的民族药理学、植物化学及药理活性方面的研究进展。为进一步研究水蛭的主要活性成分及其作用机制提供了潜在的指导意义。
Hirudo (Shuizhi in Chinese) is an important Chinese medicine, which possesses many therapeutic properties for the treatment of the cerebral hemorrhage and other thrombosis-related diseases. The phytochemical investigation gave more than 51 compounds including pteridines, phosphatidylcholines, glycosphingolipids, and sterols, as well as some bioactive peptides from the Shuizhi derived from three animal species recorded in the current Chinese Pharmacopoeia. The pharmacological studies on the Shuizhi have revealed various activities such as anticoagulation, antithrombosis, antiatherosclerosis, antiplatelet aggregation, antitumor and anti-inflammatory as well as hemorheology improvement, and protective effects against cerebral ischemia-reperfusion injury. However, some important issues based on the traditional uses of Shuizhi are still not clear. The aim of the present review is to provide comprehensive knowledge on the ethnopharmacology, phytochemistry, and pharmacological activities of Shuizhi. It will provide a potential guidance in exploring main active compounds of Shuizhi and interpreting the action mechanism for the further research.