Age-related decline in left ventricular filling at rest and exercise.
Age-related decline in left ventricular filling at rest and exercise.
复制标题
休息和运动时左心室充盈与年龄相关的下降。
DOI：
10.1152/ajpheart.1992.263.6.h1932
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Gerstenblith,G
中科院分区：
文献类型：
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作者：
Schulman,SP;Lakatta,EG;Fleg,JL;Lakatta,L;Becker,LC;Gerstenblith,G
为了确定有氧运动期间静息左心室舒张期充盈的年龄相关性下降是否持续，对88名年龄在22-82岁的健康男性进行了门控核素血池扫描，测量了静息和踏车运动充盈指数。为了评估体能状况对这些年龄相关变化的影响，一部分受试者包括经过耐力训练的高级运动员，他们的最大耗氧量为50.5+/-5，而年龄匹配的对照组为32.6+/-7mL.kg-1×min-1。测试前给另一组受试者静脉注射心得安，以评估β-肾上腺素能刺激对运动诱导的充盈变化的作用。各年龄段峰值充盈率随运动负荷的增加而递增。安静时最大充盈率、50%最大运动量、最大运动量与年龄呈负相关(r分别为-0.64、-0.53、-0.64)。老年运动员的休息和运动充盈指数与久坐不动的老年人相似。心得安降低年轻受试者(37.2+/-7.5岁)的运动高峰充盈率，但对老年受试者(62.1+/-6岁)没有影响。因此，在年轻和年长的健康男性中，随着运动的进行，充盈率都会增加，但在可比的相对工作量上，年龄差异仍然存在。这种下降并不是身体条件状态下降的次要原因，而似乎与老年人的β-肾上腺素能反应性下降有关。
To determine whether the age-associated decline in resting left ventricular diastolic filling persists during aerobic exercise, rest and bicycle exercise filling indexes were measured from gated radionuclide blood pool scans in 88 healthy men aged 22–82 yr. To evaluate the effect of physical conditioning status on these age-related changes, a subset of the subjects consisted of endurance-trained senior athletes with a maximal O2 consumption of 50.5 +/- 5 compared with 32.6 +/- 7 ml.kg-1 x min-1 in age-matched controls. The contribution of beta-adrenergic stimulation to exercise-induced changes in filling was also evaluated by the administration of intravenous propranolol to another subset before testing. Peak filling rate increased progressively at all ages with increasing exercise work loads. The peak filling rates at rest, 50% maximal exercise, and maximum exercise inversely correlated with age (r = -0.64, -0.53, -0.64, respectively). Rest and exercise filling indexes in senior athletes were similar to those of sedentary older subjects. Propranolol decreased exercise peak filling rates in young (37.2 +/- 7.5 yr) but not in older (62.1 +/- 6 yr) subjects. Therefore, filling rates increase with exercise in both young and older healthy men, but age differences persist at comparable relative work loads. This decline is not secondary to a decline in physical conditioning status but appears to be related to a decrease in beta-adrenergic responsiveness in older individuals.