5′-Homoneplanocin A inhibits hepatitis B and hepatitis C
5′-Homoneplanocin A inhibits hepatitis B and hepatitis C
复制标题
DOI：
10.1021/jm058200e
复制
发表时间：
2005-07-28
影响因子：
7.3
通讯作者：
Korba, B
中科院分区：
文献类型：
--
作者：
Yang, MM;Schneller, SW;Korba, B
作为我们开发高效合成5‘-HomonePlanocin A的计划的结果，其抗病毒潜力的探索超出了文献中已有的研究。由此，这种化合物被发现对乙肝和丙型肝炎具有有意义的活性，这代表了一种药物对这两种病毒都有效的例子。报道了这些数据和改进的5‘-高松草素A的制备方法。
As an outgrowth of our program to develop an efficient synthesis of 5'-homoneplanocin A, its antiviral potential was explored beyond that already in the literature. From that, this compound was found to have meaningful activity toward hepatitis B and hepatitis C, which represents an example of one agent effective toward both viruses. These data and an improved preparation of 5'-homoneplanocin A are reported.