Effect of Dextran 500 on radial migration of erythrocytes in postcapillary venules at low flow rates
Effect of Dextran 500 on radial migration of erythrocytes in postcapillary venules at low flow rates
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低流速下右旋糖酐 500 对毛细血管后微静脉中红细胞径向迁移的影响
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
P. Johnson
中科院分区：
文献类型：
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作者：
Sangho Kim;P. Ong;P. Johnson
最近，我们报道了红细胞之间的碰撞效率是毛细血管后小静脉聚集形成的一个重要因素。在本研究中，我们重点研究了高分子量葡聚糖如何影响毛细血管后微静脉中红细胞在距离分叉50μm的纵向距离上的整体径向迁移趋势，这反过来又会影响这些细胞的碰撞行为。用来定义单个细胞相对于血管中心的径向迁移程度的径向迁移指数，在注射葡聚糖后(1.9±2.73)比注射前(1.48±3.89)有更大的幅度。这表明，葡聚糖诱导的聚集可能提供了一种外力，使细胞主动向血管中心线移动，这可能有助于更多的红细胞参与碰撞(增加16%)和聚集形成。对单个红细胞碰撞行为的进一步分析表明，经葡聚糖处理后，单个红细胞的碰撞频率从宽范围(1到14)下降到窄范围(1到5)，这表明沿着流动方向聚集的存在改变了红细胞的碰撞行为。
Recently, we reported that collision efficiency between red blood cells were an important factor in the formation of aggregates in postcapillary venules. In the present study, we focus on how high molecular weight dextran influences the overall radial migration trend of red blood cells in the postcapillary venule along a longitudinal distance of 50 μm from the bifurcation which would in turn affect collision behavior of these cells. A radial migration index, which defines the extent of radial migration of individual cells relative to the vessel center, was found to have a larger magnitude after infusion of dextran (1.9 ± 2.73) compared to that before dextran infusion (1.48 ± 3.89). This implied that dextran‐induced aggregation might provide an external force to actively move cells towards the centerline of the vessel, which could contribute to the greater number of red blood cells participating in collision (16% increase) and aggregate formation. Further analysis of the collision behavior of individual red blood cells revealed that collision frequencies of individual cells decreased from a wide range (1 to 14) to a narrow range (1 to 5) after dextran treatment, indicating the alteration of collision behavior of red blood cells by the presence of aggregates along the flow stream.