HALOPERIDOL VERSUS THIORIDAZINE FOR HOSPITALIZED PSYCHOGERIATRIC PATIENTS: DOUBLE‐BLIND STUDY *
HALOPERIDOL VERSUS THIORIDAZINE FOR HOSPITALIZED PSYCHOGERIATRIC PATIENTS: DOUBLE‐BLIND STUDY *
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氟哌啶醇与硫利达嗪治疗住院精神病患者的比较：双盲研究*
DOI：
10.1111/j.1532-5415.1971.tb02580.x
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发表时间：
1971
影响因子：
6.3
通讯作者：
J. Cole
中科院分区：
文献类型：
--
作者：
Min‐Min Tsuang;Leighman Lu;B. Stotsky;J. Cole
在波士顿州立医院的60例老年活动性精神病患者中开始了一项为期12周的双盲研究，以比较氟哌啶醇与硫利达嗪的精神药理学疗效。剂量是灵活的，一开始的低剂量，然后逐渐增加，直到获得满意的治疗反应。氟哌啶醇的平均维持剂量约为每天2 mg，硫利达嗪的平均维持剂量为每天100-125 mg。使用的评定工具为简明精神病评定量表（BPRS）、Stotsky精神状态、临床总体印象、NOSIE-30（护士观察量表）和日常生活活动能力。在研究结束时，有50名患者可用于分析。我们的研究结果表明，两种药物组在精神病性精神病理学的许多领域都有显着下降，两种药物的作用之间没有显着差异。对于氟哌啶醇和硫利达嗪，BPRS和NOSIE-30的以下变量均出现显著（P 0.05）改善：焦虑、兴奋、易怒、敌意、多疑、幻觉行为、习惯、紧张、异常想法、情感迟钝、整洁和明显精神病。
A 12‐week double‐blind study was started with 60 actively psychotic geriatric patients residing in Boston State Hospital, to compare the psychopharmacological efficacy of haloperidol with that of thioridazine. The dosage was flexible—an initial low dosage followed by gradual increments until a satisfactory therapeutic response was obtained. Average maintenance dosages were about 2 mg a day for haloperidol and 100–125 mg a day for thioridazine. The rating instruments used were the Brief Psychiatric Rating Scale (BPRS), Stotsky Mental Status, Clinical Global Impression, NOSIE‐30 (Nurse's Observation Scale), and Activities of Daily Living. At the end of the study, 50 patients were available for analysis. Our results indicated significant decreases in many areas of psychotic psychopathology for both drug groups, without significant differences between the actions of the two drugs. For both haloperidol and thioridazine, significant (P .05) improvement occurred in the following variables on the BPRS and the NOSIE‐30: anxiety, excitement, irritability, hostility, suspiciousness, hallucinatory behavior, mannerisms, tension, unusual thoughts, blunted affect, neatness, and manifest psychosis.