Disposition kinetics of disopyramide in patients with renal insufficiency.
Disposition kinetics of disopyramide in patients with renal insufficiency.
复制标题
肾功能不全患者中丙吡胺的处置动力学。
DOI：
10.1002/bdd.2510010308
复制
发表时间：
1980
影响因子：
2.1
通讯作者：
Azarnoff,DL
中科院分区：
文献类型：
--
作者：
Shen,DD;Cunningham,JL;Shudo,I;Azarnoff,DL
The pharmacokinetics of an intravenous injection of disopyramide was studied in five normal subjects and six patients with varying degrees of renal impairment. The elimination rate constant (β) was related to the endogenous creatinine clearance (Clcr). However, a decrease in β was not observed until the Clcrwas reduced below 40 ml min−1. Below 40 ml min−1a linear relationship existed between β and Clcr. Similarly, the plasma elimination half‐life (t½β) showed a significant increase when the Clcrwas less than 30 ml min−1. Hence, dosage modification for disopyramide is necessary only when renal function is severely impaired. Overall, the apparent volume of distribution in patients with renal insufficiency was reduced to two‐thirds of that in normal subjects. Therefore, in patients with Clcrless than 40 ml min−1both the loading and maintenance dose of disopyramide should be reduced.
