Chemical inhibition of plaque.
Chemical inhibition of plaque.
复制标题
斑块的化学抑制。
DOI：
10.1111/j.1600-051x.1980.tb02150.x
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发表时间：
1980
影响因子：
6.7
通讯作者：
P. Hull
中科院分区：
文献类型：
--
作者：
P. Hull
综述了利用酶、抗生素和防腐剂等化学手段控制斑块的尝试。粘蛋白酶、脱水胰腺、真菌来源的酶、葡聚糖酶和突变酶等酶尽管在体外和动物研究中前景看好，但临床上的成功有限。观察了使用酶的副作用。许多抗生素已经被用来试图控制斑块，其中几种已经成功。然而，长期使用此类药物存在问题，使其无法作为控制斑块的常规药物使用。双胍基洗必泰是目前应用最广泛、研究最多的化学菌斑控制方法。许多研究已经证明，它将成功地控制斑块。长期使用它没有毒副作用的报道，但确实出现了局部副作用，如牙齿染色。季铵化合物目前没有比双胍更好的优势，需要更频繁地使用才能达到与洗必泰相同程度的菌斑控制。
Attempts to control plaque by chemical means using enzymes, antibiotics and antiseptics are reviewed. Enzymes such as mucinase, dehydrated pancreas, enzymes of fungal origin, dextranase and mutanase showed limited clinical success despite promising in vitro and animal studies. Side effects from the use of enzymes were observed. Many antibiotics have been used in attempts to control plaque and several have been successful. However, problems exist from the long-term use of such drugs which precludes their routine use as agents for controlling plaque. The biguanide chlorhexidine is the most widely used and investigated method of chemical plaque control. Many studies have been demonstrated that it will successfully control plaque. No toxic side effects have been reported from its long-term use but local side effects such as staining of the teeth do occur. The quaternary ammonium compounds have at present no advantages over the biguanides and require more frequent usage to achieve the same degree of plaque control as chlorhexidine.