Analysis of Age and Disease Status as Predictors of Thyroid Cancer-Specific Mortality Using the Surveillance, Epidemiology, and End Results Database
Analysis of Age and Disease Status as Predictors of Thyroid Cancer-Specific Mortality Using the Surveillance, Epidemiology, and End Results Database
复制标题
DOI：
10.1089/thy.2014.0116
复制
发表时间：
2015-01-01
期刊：
影响因子：
6.6
通讯作者：
Bouvet, Michael
中科院分区：
文献类型：
--
作者：
Orosco, Ryan K.;Hussain, Timon;Bouvet, Michael
背景：诊断时的年龄被纳入分化型甲状腺癌（DTC）的所有相关分期系统。越来越多的证据表明，特定的年龄界限对于准确的风险分层可能并不理想。我们试图评估年龄和肿瘤变量之间的相互作用，在DTC患者使用最大的cohort to date.Methods：监测，流行病学和最终结果（SEER）数据库进行查询，以确定DTC患者作为他们唯一的恶性肿瘤为1973年至2009年期间。使用一系列年龄临界值和年龄亚组进行多变量分析，以寻找最佳年龄，提供年轻和老年患者之间最显着的风险分层。主要结果是疾病特异性生存率（DSS）和协变量包括：年龄，种族，性别，肿瘤/淋巴结/转移（TNM）阶段，十年的诊断，和放射性碘治疗。76%的患者为美国癌症联合委员会（AJCC）I期，8%为II期，7%为III期，8%为IV期。年龄超过45岁（风险比[HR] 19.2，p
Background: Age at diagnosis is incorporated into all relevant staging systems for differentiated thyroid carcinoma (DTC). There is growing evidence that a specific age cutoff may not be ideal for accurate risk stratification. We sought to evaluate the interplay between age and oncologic variables in patients with DTC using the largest cohort to date.Methods: The Surveillance, Epidemiology, and End Results (SEER) database was queried to identify patients with DTC as their only malignancy for the period 1973 to 2009. Multivariate analyses using a range of age cutoffs and age subgroupings were utilized in order to search for an optimal age that would provide the most significant risk stratification between young and old patients. The primary outcome was disease-specific survival (DSS) and covariates included: age, race, sex, tumor/nodal/metastasis (TNM) stage, decade of diagnosis, and radioactive iodine therapy.Results: A total of 85,740 patients were identified. Seventy-six percent of patients were American Joint Committee on Cancer (AJCC) stage I, 8% were stage II, 7% were stage III, and 8% were stage IV. Age over 45 years (hazard ratio [HR] 19.2, p