Aggressive periodontitis is likely influenced by a few small effect genes
Aggressive periodontitis is likely influenced by a few small effect genes
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DOI：
10.1111/j.1600-051x.2009.01410.x
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发表时间：
2009-06-01
影响因子：
6.7
通讯作者：
Vieira, Alexandre R.
中科院分区：
文献类型：
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作者：
de Carvalho, Flavia M.;Tinoco, Eduardo M. B.;Vieira, Alexandre R.
德卡瓦略 FM、蒂诺科 EMB、戈维尔 M、马拉齐塔 ML、维埃拉 AR。侵袭性牙周炎可能受到一些小效应基因的影响。临床牙周病学杂志2009； 36：468-473。 doi: 10.1111/j.1600-051X.2009.01410.x.评估具有相似地理起源的家庭集合中侵袭性牙周炎的遗传模式。利用SAGE v.5.4.2的SEGREG程序对74个家庭的家系数据进行分离分析。假设侵袭性牙周炎的患病率为 1% 并且不偏离 Hardy-Weinberg 平衡，测试了均质无透射、均质孟德尔透射、均质一般透射、半一般透射和异质一般透射模型。模型的参数是通过最大似然法估计的，它提供了每个模型的总体ln（似然）、-2ln和AIC（赤池得分）。使用似然比检验（LRT）将每个模型与完全通用模型进行比较（p>0.05）。最简约的遗传模式是半通用传播模型，它允许杂合子传播概率变化。这一结果为以下假设提供了强有力的支持：遗传因素在侵袭性牙周炎中发挥作用，并且少数位点（每个位点的影响相对较小）导致侵袭性牙周炎， 或不与环境因素相互作用。
de Carvalho FM, Tinoco EMB, Govil M, Marazita ML, Vieira AR. Aggressive periodontitis is likely influenced by a few small effect genes. J Clin Periodontol 2009; 36: 468-473. doi: 10.1111/j.1600-051X.2009.01410.x.To evaluate the inheritance mode of aggressive periodontitis in a collection of families with a similar geographic origin.Segregation analysis was performed in pedigree data from 74 families by the use of the SEGREG program of SAGE v.5.4.2. Homogeneous no transmission, homogeneous Mendelian transmission, homogeneous general transmission, semi-general transmission and heterogeneous general transmission models were tested assuming the prevalence of aggressive periodontitis as 1% and no deviations from Hardy-Weinberg equilibrium. The parameters of the model were estimated by the method of maximum likelihood, which provides the overall ln (likelihood), -2ln and the AIC (Akaike's score) for each model. The likelihood ratio test (LRT) was used to compare each model against a fully general model (p > 0.05).The most parsimonious mode of inheritance was the semi-general transmission model that allows the heterozygote transmission probability to vary.This result provides strong support for the hypothesis that genetic factors play a role in aggressive periodontitis and that a few loci, each with relatively small effects, contribute to aggressive periodontitis, with or without interaction with environmental factors.