RHOPTRY ORGANELLES OF APICOMPLEXAN PARASITES
RHOPTRY ORGANELLES OF APICOMPLEXAN PARASITES
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DOI：
10.1016/0169-4758(92)90308-o
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发表时间：
1992-01-01
期刊：
影响因子：
--
通讯作者：
PERKINS, ME
中科院分区：
文献类型：
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作者：
PERKINS, ME
弓形体是胞内、顶复合体寄生物的统一结构特征，在宿主细胞侵袭中起着核心作用。不同属的zoite的超微结构研究表明，参与侵染宿主细胞的异构体在形态上是相似的。然而，对其蛋白质成分的生化分析表明，不同球虫寄生虫之间存在相当程度的多样性。在这篇文章中，Margaret Perkins提出了一个问题，即不同属的弓形体成分是否存在共同的结构决定因素，以及所有顶复合体寄生虫的弓形体功能的潜在机制是否相似。
Rhoptries are the unifying structural feature of the intracellar, apicomplexan parasites and are implicated in having a central role in host cell invasion. Ultrastructural studies of zoites of different genera suggest that the participation of rhoptries in the invasion of the respective host cells is morphologically similar. However, biochemical analysis of their protein constituents reveals a considerable degree of diversity between different coccidian parasites. In this article Margaret Perkins asks whether there are common structural determinants of the rhoptry components of different genera and if the underlying mechanism of rhoptry function is similar in all apicomplexan parasites.