Insulin and epidermal growth factor stimulate poly ADP-ribosylation.
Insulin and epidermal growth factor stimulate poly ADP-ribosylation.
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胰岛素和表皮生长因子刺激聚 ADP 核糖基化。
DOI：
10.1016/0006-291x(81)91778-2
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发表时间：
1981
影响因子：
3.1
通讯作者：
Shimizu,N
中科院分区：
文献类型：
--
作者：
Shimizu,Y;Shimizu,N
摘要 用胰岛素或表皮生长因子处理接触抑制的 BALBc 3T3 成纤维细胞，可显着提高聚 (ADP-核糖) 合成能力。在长期激素处理（18 小时）后观察到聚 ADP-核糖基化的刺激，但在短期处理（1 小时）后未观察到，并且它似乎与细胞进入 DNA 合成相关。发现多种细胞成分的聚 ADP 核糖基化得到增强。数据表明聚 ADP-核糖基化在多肽激素和生长因子的促有丝分裂作用中可能发挥作用。
Abstract Treatment of contact-inhibited BALBc 3T3 fibroblasts with insulin or epidermal growth factor elicited a considerable increase in the capacity of poly (ADP-ribose) synthesis. Stimulation of the poly ADP-ribosylation was observed after long-term hormone treatment (18 hours) but not after short-term treatment (1 hour) and it appeared to be correlated with the cell's entry into DNA synthesis. Several cellular components were found to be enhanced in poly ADP-ribosylation. The data suggest a possible role for poly ADP-ribosylation in mitogenic action of polypeptide hormones and growth factors.