The long-term effects of prematurity and intrauterine growth restriction on cardiovascular, renal, and metabolic function.
The long-term effects of prematurity and intrauterine growth restriction on cardiovascular, renal, and metabolic function.
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DOI：
10.1155/2010/280402
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发表时间：
2010
影响因子：
2.1
通讯作者：
Gallery ED
中科院分区：
文献类型：
--
作者：
Chan PY;Morris JM;Leslie GI;Kelly PJ;Gallery ED
客观的。确定宫内生长受限（IUGR）和早产对青春期儿童心血管、肾脏或代谢功能障碍风险的相对影响。研究设计。回顾性队列研究。 71名青春期儿童被分为四组：小于胎龄早产儿（SGA）、适合胎龄早产儿（AGA）、足月SGA和足月AGA。结果措施。蛋白质负荷后的收缩压 (SBP)、增强指数 (Al)、肾小球滤过率 (GFR)；血浆葡萄糖和血清胰岛素水平。结果。与 AGA 相比，SGA 具有较高的 SBP（平均 4.6 mmHg）和较低的蛋白质负荷后 GFR（平均 28.5 mL/min/1.73 m2）。早产对 SBP (P = .4) 或 GFR (P = .9) 没有影响。与所有其他组相比，早产儿和 SGA 都与较高的 AI（平均 9.7%）和葡萄糖负荷后 2 小时较高的血清胰岛素水平（平均 15.5 mIU/L）相关。结论。对于晚期收缩期高血压和肾功能不全，IUGR 是比早产更重要的危险因素。在早产儿中，患有 SGA 的儿童出现动脉硬化和代谢功能障碍的风险增加。
Objective. To determine relative influences of intrauterine growth restriction (IUGR) and preterm birth on risks of cardiovascular, renal, or metabolic dysfunction in adolescent children. Study Design. Retrospective cohort study. 71 periadolescent children were classified into four groups: premature small for gestational age (SGA), premature appropriate for gestational age (AGA), term SGA, and term AGA. Outcome Measures. Systolic blood pressure (SBP), augmentation index (Al), glomerular filtration rate (GFR) following protein load; plasma glucose and serum insulin levels. Results. SGA had higher SBP (average 4.6 mmHg) and lower GFR following protein load (average 28.5 mL/min/1.73 m2) than AGA. There was no effect of prematurity on SBP (P = .4) or GFR (P = .9). Both prematurity and SGA were associated with higher AI (average 9.7%) and higher serum insulin levels 2 hr after glucose load (average 15.5 mIU/L) than all other groups. Conclusion. IUGR is a more significant risk factor than preterm birth for later systolic hypertension and renal dysfunction. Among children born preterm, those who are also SGA are at increased risk of arterial stiffness and metabolic dysfunction.