Correlations between changes in hematological indices of mothers with preeclampsia and umbilical cord blood of newborns
Correlations between changes in hematological indices of mothers with preeclampsia and umbilical cord blood of newborns
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DOI：
10.1080/10641963.2018.1441861
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发表时间：
2019-01-02
影响因子：
12.3
通讯作者：
Alhag, Samaher M.
中科院分区：
文献类型：
--
作者：
Elgari, Mahmoud M.;Khabour, Omar F.;Alhag, Samaher M.
先兆子痫是一种可能严重影响母亲及其新生儿健康的疾病。本研究的目的是检查先兆子痫母亲和脐带血的血液学参数。在这项研究中招募了80名先兆子痫的母亲。另取80例正常孕妇作为对照组。检查血液学参数包括血红蛋白（Hb）、红细胞计数（RBC）、红细胞分布宽度（RDW）、红细胞压积（PCV）、平均红细胞体积（MCV）、平均红细胞血红蛋白（MCH）、平均红细胞血红蛋白浓度（MCHC）、白色细胞计数（WBC）、血小板计数、平均血小板体积（MPV）和血小板大细胞比率（PLCR）。结果显示，先兆子痫与低出生体重、早产/剖宫产和蛋白尿密切相关（P < 0.001）。血红蛋白和中性粒细胞明显低于正常人（P < 0.01），红细胞体积、红细胞压积、红细胞平均体积、红细胞平均血红蛋白含量、红细胞平均血红蛋白含量和淋巴细胞明显高于正常人（P < 0.01）。当先兆子痫母亲的脐带血与正常的比较，观察到类似的结果。此外，结果显示，先兆子痫母亲和他们的新生儿之间的血红蛋白显着和正相关（r2 = 0.075，P < 0.05），PCV（r2 = 0.084，P < 0.01）、MCV（r2 = 0.077，P < 0.05）、MCHC（r2 = 0.115，P < 0.01）、RBC（r2 = 0.086，P < 0.01）和Retics（r2 = 0.306，P < 0.01）。总之，与先兆子痫相关的几个血液学参数的变化与受影响的母亲及其新生儿相关。这些生物标志物可用于预测先兆子痫妇女的妊娠结局。
Preeclampsia is a condition that might severely impact the health of mothers and their newborns. The aim of this investigation is to examine hematological parameters in mothers with preeclampsia and umbilical cord blood. Eighty preecalmptic mothers were recruited in the study. In addition, eighty normal pregnant mothers served as controls. Hematological parameters that include hemoglobin (Hb), red blood cell count (RBC), red cell distribution width (RDW), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), white blood cell counts (WBC), platelet counts, mean platelet volume (MPV) and Platelet large cell ratio (PLCR) were examined. Results showed a strong association between preeclampsia and low birth weight, premature/cesarean delivery and proteinuria (P < 0.001). Hb and neutrophils were significantly lower (P < 0.01), whereas RDW, PCV, MCV, MCH, MCHC and lymphocytes were significantly higher than normal ones (P < 0.01). When cord blood of preeclamptic mothers were compared with that of normal ones, similar findings were observed. In addition, results showed significant and positive correlations between preeclamptic mothers and their newborn in Hb (r2 = 0.075, P < 0.05), PCV (r2 = 0.084, P < 0.01), MCV (r2 = 0.077, P < 0.05), MCHC (r2 = 0.115, P < 0.01), RBC (r2 = 0.086, P < 0.01) and retics (r2 = 0.306, P < 0.01). In conclusion, changes in several hematological parameters associated with preeclampsia were correlated in affected mothers and their newborns. Such biomarkers can be used to predict pregnancy outcomes in women with preeclampsia.