Subdiaphragmatic vagotomy does not prevent fever following intracerebroventricular prostaglandin E2: further evidence for the importance of vagal afferents in immune-to-brain communication.
Subdiaphragmatic vagotomy does not prevent fever following intracerebroventricular prostaglandin E2: further evidence for the importance of vagal afferents in immune-to-brain communication.
复制标题
膈下迷走神经切断术不能预防脑室内前列腺素 E2 后的发热：进一步证明迷走神经传入在免疫与大脑通讯中的重要性。
DOI：
10.1016/s0006-8993(97)00705-1
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发表时间：
1997
期刊：
影响因子：
2.9
通讯作者：
Maier,SF
中科院分区：
文献类型：
--
作者：
Milligan,ED;McGorry,MM;Fleshner,M;Gaykema,RP;Goehler,LE;Watkins,LR;Maier,SF
脑介导的疾病反应可以被迷走神经切断术阻断，这表明迷走神经传入信号周围炎症或感染。这项研究测试了是否下迷走神经切断术中断效应通路干扰疾病反应。如果这个解释是正确的，那么脑室内前列腺素E2引起的发热应该被这个过程阻断。发热不受蛛网膜下迷走神经切断术的影响，因此这些数据支持迷走神经传入信号在免疫激活过程中向大脑发出的结论。
Brain-mediated sickness responses can be blocked by subdiaphragmatic vagotomy, suggesting that vagal afferents signal peripheral inflammation or infection. This study tested whether subdiaphragmatic vagotomy disrupts sickness responses by interrupting effector pathways. If this explanation is correct, intracerebroventricular prostaglandin E2-induced fever should be blocked by this procedure. Fever was unaffected by subdiaphragmatic vagotomy, thus these data provide support for the conclusion that vagal afferents signal the brain during immune activation.