COMPUTERIZED-TOMOGRAPHY IN TARDIVE-DYSKINESIA - EVIDENCE OF STRUCTURAL ABNORMALITIES IN THE BASAL GANGLIA SYSTEM
COMPUTERIZED-TOMOGRAPHY IN TARDIVE-DYSKINESIA - EVIDENCE OF STRUCTURAL ABNORMALITIES IN THE BASAL GANGLIA SYSTEM
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DOI：
10.1007/bf00346087
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发表时间：
1983-01-01
影响因子：
--
通讯作者：
THEMELIS, J
中科院分区：
文献类型：
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作者：
BARTELS, M;THEMELIS, J
29例患有中度至重度迟发性运动障碍（TD）的患者和29例年龄和性别匹配的对照组(C)接受与患者相当的长期抗精神病药物治疗，均使用计算机断层扫描进行检查。两组在第三脑室宽度（TD > C）、双尾核距离（TD > C）、尾状核头部计算面积（TD < C）和透镜状核面积（TD < C）上差异均有统计学意义。心室和细胞介质指数无显著差异。显然，结构异常，主要是在基底神经节系统，存在于TD患者。Benton视觉保留测试的心理测试也显示了TD患者在脑器质性功能障碍方面的显著差异。
Patients (29) with moderate to severe tardive dyskinesia (TD) and 29 age- and sex-matched controls (C) with long-term neuroleptic therapy comparable to that of the patients were all examined using computerized tomography. Significant differences were found between the 2 groups in the width of the 3rd ventricle (TD > C), the bicaudate distance (TD > C), the computed area of the head of the caudate nucleus (TD < C) and the area of the lenticular nucleus (TD < C). No significant differences were established in the ventricular or cella media indices. Evidently, structural abnormalities, primarily in the basal ganglia system, are present in TD patients. Psychological testing with the Benton visual retention test also showed significant differences with regard to cerebro-organic functional impairment among TD patients.