Reduced glutamate in the anterior cingulate cortex in depression:: An in vivo proton magnetic resonance spectroscopy study
Reduced glutamate in the anterior cingulate cortex in depression:: An in vivo proton magnetic resonance spectroscopy study
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DOI：
10.1016/s0006-3223(99)00159-6
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发表时间：
2000-02-15
影响因子：
10.6
通讯作者：
Holsboer, F
中科院分区：
文献类型：
--
作者：
Auer, DP;Pütz, B;Holsboer, F
背景：功能影像学研究表明，前脑区在抑郁症的发病机制中具有特殊的作用。本研究的目的是利用体内质子磁共振波谱（H-1-MRS）评估重度抑郁发作患者前内侧皮层可能的神经化学改变。对19名重度抑郁发作患者和18名年龄匹配的健康对照者在前扣带回皮质和顶叶白色物质内进行了单体素H-1-MRS。估计N-的绝对浓度乙酰天冬氨酸、含胆碱化合物、总肌酸、肌醇、未分离的谷氨酸和谷氨酰胺（Glx）以及单独的谷氨酸（Glu）。体素组成tvas分析的图像分割成脑脊液（CSF），灰色和白色matter.Results：MANOVA测试的Glx和Gill使用年龄，百分之CSF和百分之灰质贡献作为协变量，产生了显着的组效应内的前扣带回由于减少Glx的患者（-10.4%，p = 0.13）。仅考虑重度抑郁患者，Glx和Glu（-14.3%，p = 0.03）均显示显著降低。有没有显着的组效应的神经元标记NAA，肌酸，胆碱或肌醇在任何localization.Conclusions：这项研究表明，可能的作用改变amatergic神经传递内的前扣带回的发病机制的情绪障碍。主要脑代谢物的其他不显著的发现证实了重度抑郁症中缺乏神经退行性或膜代谢变化，Biol Psychiatry 2000;47：305-313（C）2000 Society of Biological Psychiatry。
Background: Functional imaging studies suggest a specific role of the anterior brain regions in the pathogenesis of major depression. The aim of this study was to evaluate possible neurochemical alterations in the frontomesial cortex in patients with major depressive episode using in vivo proton magnetic resonance spectroscopy (H-1-MRS).Methods: Single voxel H-1-MRS was performed in 19 patients with major depressive episodes and 18 age-matched healthy controls within the anterior cingulate cortex and the parietal white matter Absolute concentrations were estimated for N-acetyl-aspartate, choline-containing compounds, total creatine, myo-inositol, unresolved glutamate and glutamine (Glx) and glutamate alone (Glu). Voxel composition tvas analyzed by image segmentation into cerebrospinal fluid (CSF), grey and white matter.Results: MANOVA test for Glx and Gill using age, percent CSF and percent grey matter contribution as covariates yielded a significant group effect within the anterior cingulate due to decrease of Glx in patients (-10.4%, p =,013). Considering only severely depressed patients, both Glx and Glu (-14.3%, p =.03) showed a significant decrease. There was no significant group effect for the neuronal marker NAA, creatine, choline or myo-inositol in either localization.Conclusions: This study suggests a possible role of altered glutamatergic neurotransmission within the anterior cingulate in the pathogenesis of mood disorders. The otherwise unremarkable findings of major brain metabolites confirms lack of neurodegenerative or membrane metabolic changes in major depression, Biol Psychiatry 2000;47:305-313 (C) 2000 Society of Biological Psychiatry.