Noninvasive in vivo human coronary artery lumen and wall imaging using black-blood magnetic resonance imaging.
Noninvasive in vivo human coronary artery lumen and wall imaging using black-blood magnetic resonance imaging.
复制标题
使用黑血磁共振成像进行无创体内人冠状动脉管腔和管壁成像。
DOI：
10.1161/01.cir.102.5.506
复制
发表时间：
2000
期刊：
影响因子：
37.8
通讯作者：
Sharma,SK
中科院分区：
文献类型：
--
作者：
Fayad,ZA;Fuster,V;Fallon,JT;Jayasundera,T;Worthley,SG;Helft,G;Aguinaldo,JG;Badimon,JJ;Sharma,SK
背景-高分辨率MRI具有无创性地对人体冠状动脉壁成像并确定冠状动脉疾病的程度和性质的潜力。冠状动脉成像的MR已被限制的伪影有关的血流和运动，并通过低spatial resolution.Methods和结果，我们使用了一种非侵入性的黑血（BB）MRI（BB-MR）的方法，免费的运动和血流伪影，高分辨率（下降到0.46毫米的平面分辨率和3毫米层厚）成像的冠状动脉腔和壁。对13例正常人和冠状动脉粥样硬化患者（8例正常人和5例冠状动脉疾病患者）进行了活体BB-MR检查。正常受试者每个横断面图像的平均冠状动脉壁厚度为0.75±0.17 mm（范围为0.55 ~ 1.0 mm）。通过X线血管造影评估的狭窄≥40%患者的冠状动脉MR图像显示局部壁厚为4.38±0.71 mm（范围：3.30 - 5.73 mm）。正常人和患者之间的最大壁厚的差异有统计学意义（P<0.0001）。结论-在体内高空间分辨率BB-MR提供了一种独特的新方法，无创成像和评估人类冠状动脉的形态特征。这可能允许在动脉粥样硬化疾病出现症状之前对其进行识别。有必要进一步研究，以确定不同的斑块成分，并评估无症状患者的病变及其结果。
Background—High-resolution MRI has the potential to noninvasively image the human coronary artery wall and define the degree and nature of coronary artery disease. Coronary artery imaging by MR has been limited by artifacts related to blood flow and motion and by low spatial resolution.Methods and Results—We used a noninvasive black-blood (BB) MRI (BB-MR) method, free of motion and blood-flow artifacts, for high-resolution (down to 0.46 mm in-plane resolution and 3-mm slice thickness) imaging of the coronary artery lumen and wall. In vivo BB-MR of both normal and atherosclerotic human coronary arteries was performed in 13 subjects: 8 normal subjects and 5 patients with coronary artery disease. The average coronary wall thickness for each cross-sectional image was 0.75±0.17 mm (range, 0.55 to 1.0 mm) in the normal subjects. MR images of coronary arteries in patients with ≥40% stenosis as assessed by x-ray angiography showed localized wall thickness of 4.38±0.71 mm (range, 3.30 to 5.73 mm). The difference in maximum wall thickness between the normal subjects and patients was statistically significant (P<0.0001).Conclusions—In vivo high-spatial-resolution BB-MR provides a unique new method to noninvasively image and assess the morphological features of human coronary arteries. This may allow the identification of atherosclerotic disease before it is symptomatic. Further studies are necessary to identify the different plaque components and to assess lesions in asymptomatic patients and their outcomes.