Descriptive epidemiology of autism in a California population: Who is at risk?
Descriptive epidemiology of autism in a California population: Who is at risk?
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DOI：
10.1023/a:1015405914950
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发表时间：
2002-06-01
影响因子：
3.9
通讯作者：
Selvin, S
中科院分区：
文献类型：
--
作者：
Croen, LA;Grether, JK;Selvin, S
我们调查了选定的婴儿和母亲特征与自闭症风险之间的关系。1989-1994年在加州出生的自闭症儿童通过服务机构记录进行鉴定，并根据出生证明上记录的特定特征与加州活产儿总数进行比较。多变量模型用于产生调整后的风险估计。在350多万活产人口中，4381名自闭症儿童被确诊。男性、多胞胎和黑人母亲所生的孩子的风险增加。风险随着母亲年龄和受教育程度的增加而增加。与加州出生的母亲相比，移民母亲所生的孩子的风险相似或更低。与这些人口统计学特征相关的环境因素可能与遗传易感性相互作用，从而增加患自闭症的风险。
We investigated the association between selected infant and maternal characteristics and autism risk. Children with autism born in California in 1989-1994 were identified through service agency records and compared with the total population of California live births for selected characteristics recorded on the birth certificate. Multivariate models were used to generate adjusted risk estimates. From a live birth population of more than 3.5 million, 4381 children with autism were identified. Increased risks were observed for males, multiple births, and children born to black mothers. Risk increased as maternal age and maternal education increased. Children born to immigrant mothers had similar or decreased risk compared with California-born mothers. Environmental factors associated with these demographic characteristics may interact with genetic vulnerability to increase the risk of autism.