Overview of MicroRNAs in Cardiac Hypertrophy, Fibrosis, and Apoptosis.
Overview of MicroRNAs in Cardiac Hypertrophy, Fibrosis, and Apoptosis.
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DOI：
10.3390/ijms17050749
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发表时间：
2016-05-18
影响因子：
5.6
通讯作者：
Chen YT
中科院分区：
文献类型：
--
作者：
Wang J;Liew OW;Richards AM;Chen YT
MicroRNAs （miRNAs）是一种非编码rna，在几乎所有生物事件中调控基因表达起着至关重要的作用。在过去的十年中，在许多体外和体内研究中，已经探索了mirna在各种心血管疾病中的作用。本文就mirna的发现、靶基因及其功能等方面的研究进展进行综述。通过miRNA/3 ‘端非翻译区（3 ’ utr）相互作用试验和/或功能增益/功能丧失方法证明，本文所选择的miRNA对靶基因表达具有调节作用。列出的miRNA实体根据其靶基因与三种心血管病理（即心脏肥大、纤维化和凋亡）的生物学相关性进行分类。此外，通过对86项研究的比较，确定了几个可能在心血管疾病的个体发生中特别重要的候选mirna，因为它们调节参与多种不良心血管事件进展的靶基因簇的表达。这篇综述阐述了mirna在多种生物信号通路中的作用，并概述了目前对mirna在心血管健康和疾病中的作用的理解和研究进展。
MicroRNAs (miRNAs) are non-coding RNAs that play essential roles in modulating the gene expression in almost all biological events. In the past decade, the involvement of miRNAs in various cardiovascular disorders has been explored in numerous in vitro and in vivo studies. In this paper, studies focused upon the discovery of miRNAs, their target genes, and functionality are reviewed. The selected miRNAs discussed herein have regulatory effects on target gene expression as demonstrated by miRNA/3′ end untranslated region (3′UTR) interaction assay and/or gain/loss-of-function approaches. The listed miRNA entities are categorized according to the biological relevance of their target genes in relation to three cardiovascular pathologies, namely cardiac hypertrophy, fibrosis, and apoptosis. Furthermore, comparison across 86 studies identified several candidate miRNAs that might be of particular importance in the ontogenesis of cardiovascular diseases as they modulate the expression of clusters of target genes involved in the progression of multiple adverse cardiovascular events. This review illustrates the involvement of miRNAs in diverse biological signaling pathways and provides an overview of current understanding of, and progress of research into, of the roles of miRNAs in cardiovascular health and disease.