Estrogen-induced gonadotropin surges in female rhesus monkeys after pituitary stalk section.
Estrogen-induced gonadotropin surges in female rhesus monkeys after pituitary stalk section.
复制标题
垂体柄切除后雌性恒河猴体内雌激素诱导的促性腺激素激增。
DOI：
10.1210/endo-104-1-50
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发表时间：
1979
期刊：
影响因子：
4.8
通讯作者：
R. L. Wiele
中科院分区：
文献类型：
--
作者：
M. Ferin;Howard Rosenblatt;P. Carmel;J. Antunes;R. L. Wiele
为了探讨雌二醇的主要作用部位，无论是垂体还是下丘脑，我们研究了雌性恒河猴垂体柄切除前后促性腺激素对雌激素的反应。雌激素挑战，包括注射苯甲酸雌二醇（400微克）或植入三个含有17 -雌二醇的硅胶胶囊，在月经周期的第2- 5天开始。在茎切片后不迟于8 h给予雌激素。雌激素诱导5只动物茎秆切除前后LH升高。在5只完整动物中的4只和4只茎秆切片动物中的3只中观察到卵泡刺激素增加。在三个茎切动物中，仅用油处理的平均FSH和LH水平与注射前对照组没有显着差异。这些实验表明，雌性激素对猕猴促性腺激素释放的影响很可能存在于脑垂体本身。
In order to investigate the primary site of action of estradiol, whether pituitary or hypothalamic, gonadotropin responses to estrogen were studied in female rhesus monkeys before and immediately after pituitary stalk section. The estrogen challenge, consisting of either an injection of estradio benzoate (400 microgram) or an implant of three silastic capsules containing 17 beta-estradiol, was initiated on days 2--5 of the menstrual cycle. The estrogen was given not later than 8 h after stalk section. Estrogens induced LH surges in all five animals before and after stalk section. FSH increases were observed in four of five intact and three of four stalk-sectioned animals. Mean FSH and LH levels in three stalk-sectioned animals treated with oil alone did not differ significantly from preinjection controls. These experiments suggest that the locus of estrogens on gonadotropin release in the rhesus monkey may well reside within the pituitary gland itself.