Vitamin D and Asthma
Vitamin D and Asthma
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DOI：
10.1164/rccm.201108-1502ci
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发表时间：
2012-01-15
影响因子：
24.7
通讯作者：
Celedon, Juan C.
中科院分区：
文献类型：
--
作者：
Paul, Grace;Brehm, John M.;Celedon, Juan C.
维生素D缺乏症和哮喘是共同的风险因素，如非洲裔美国人种族，市中心居住和肥胖。本文综述了维生素D状态与哮喘或哮喘发病率之间因果关系的实验和流行病学证据，包括潜在的保护机制，如抗病毒作用和增强类固醇反应性。由于大多数已发表的关于维生素D与哮喘或哮喘发病率的流行病学研究都是观察性的，因此建议或反对补充维生素D作为哮喘的预防或二级治疗是不可取的，必须等待正在进行的临床试验的结果。如果这些试验证实了维生素D的有益作用，则需要其他试验来评估维生素D补充剂在预防或治疗不同人群（如婴儿，学龄儿童和少数民族）哮喘中的作用。
Vitamin D deficiency and asthma are common conditions that share risk factors such as African American ethnicity, inner-city residence, and obesity. This review provides a critical examination of current experimental and epidemiologic evidence of a causal association between vitamin D status and asthma or asthma morbidity, including potential protective mechanisms such as antiviral effects and enhanced steroid responsiveness. Because most published epidemiologic studies of vitamin D and asthma or asthma morbidity are observational, a recommendation for or against vitamin D supplementation as preventive or secondary treatment for asthma is not advisable and must await results of ongoing clinical trials. Should these trials confirm a beneficial effect of vitamin D, others will be needed to assess the role of vitamin D supplementation to prevent or treat asthma in different groups such as infants, children of school age, and ethnic minorities.