Quality-of-Life Metrics Correlate With Disease Severity in Idiopathic Subglottic Stenosis
Quality-of-Life Metrics Correlate With Disease Severity in Idiopathic Subglottic Stenosis
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DOI：
10.1002/lary.26930
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发表时间：
2018-06-01
期刊：
影响因子：
2.6
通讯作者：
Franco, Ramon A., Jr.
中科院分区：
文献类型：
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作者：
Naunheim, Matthew R.;Paddle, Paul M.;Franco, Ramon A., Jr.
目的特发性声门下狭窄(ISGS)对生活质量(QOL)有显著影响，但目前尚不清楚患者的主观反应与疾病严重程度的客观测量之间的关系。最大呼气流量百分比(PEF%)已被证明是声门下狭窄疾病严重程度的有效量度。本研究旨在找出与PEF%相关的关键生活质量问题，并提出一个预测疾病严重程度的统计模型。方法对2012-2016年间一位喉科专家就诊的ISGS患者进行回顾性研究。记录每次访问的最大呼气流量百分比(年龄、性别和身高调整后)，以及四种有效的生活质量工具(欧洲生活质量-5维；兰德36项健康调查；临床COPD[慢性阻塞性肺疾病]问卷；以及呼吸道、呼吸困难、嗓音和吞咽摘要评估)。采用逐步多元线性回归方法筛选出与PEF%相关的自变量，并建立模型。四种生活质量量表的总分与每次就诊时记录的PEF%值相关(P
ObjectivesIdiopathic subglottic stenosis (ISGS) can have significant impacts on quality of life (QOL), but it remains unclear how patients' subjective responses correlate with objective measurement of disease severity. Peak expiratory flow percentage (PEF%) has been shown to be an effective measure of disease severity in subglottic stenosis. This study aims to identify the key QOL questions correlated with PEF% and proposes a statistical model for prediction of disease severity.MethodsPatients with ISGS presenting to an academic laryngologist were included retrospectively from 2012 to 2016. Peak expiratory flow percentage (age, sex, and height adjusted) was recorded for each visit, along with four validated QOL instruments (European QOL-Five Dimensions; RAND 36-Item Health Survey; Clinical COPD [Chronic Obstructive Pulmonary Disease] Questionnaire; and the Airway, Dyspnea, Voice, and Swallowing Summary Assessment). A stepwise multiple linear regression was used to identify statistically significant independent variables correlated with PEF%, and a model was built with these variables.ResultsThirty-two patients were included, with a total of 271 patient encounters. Overall scores from each of the four QOL instruments were correlated with PEF% values recorded each visit (P