Numerical simulation of pre- and postsurgical flow in a giant basilar aneurysm
Numerical simulation of pre- and postsurgical flow in a giant basilar aneurysm
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DOI：
10.1115/1.2898833
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发表时间：
2008-04-01
影响因子：
1.7
通讯作者：
Saloner, David
中科院分区：
文献类型：
--
作者：
Rayz, Vitaliy L.;Lawton, Michael T.;Saloner, David
脑动脉瘤血流的计算模型是一项不断发展的技术，在手术计划中可能发挥重要作用。在这项研究中，我们模拟了一个巨大的基底动脉瘤在手术切除一个椎动脉之前和之后的血流。通过磁共振（MR）血管造影和流速仪获得的患者特异性几何形状和流速用于模拟手术前后的血流。得到了稳定流和脉动流的数值解。在动脉瘤中计算了高度三维流，并伴有强烈的二次流。在术前和术后的情况下。计算结果预测，椎动脉闭塞将导致动脉瘤凸起处形成的慢流区显著增加，计算出颗粒停留时间增加，速度低于2.5 cm/s。手术后发现血流缓慢的区域充满了血栓。数字预测。模拟方法与动脉瘤手术治疗后观察到的结果一致。该研究表明，计算模型可以为未来的研究提供假设，并可能为脑动脉瘤的介入治疗提供指导。
Computational modeling of the flow in cerebral aneurysms is an evolving technique that may play an important role in surgical planning. In this study, we simulated the flow in a giant basilar aneurysm before an after surgical takedown of one vertebral artery. Patient-specific geometry and flowrates obtained from-magnetic resonance (MR) angiography and velocimetry were used to simulate the flow prior to and after the surgery. Numerical solutions for steady and pulsatile flows were obtained. Highly three-dimensional flows, with strong secondary flows, were computed in the aneurysm. in the presurgical and postsurgical conditions. The computational results predicted that occlusion of a vertebral artery would result in a significant increase of the slow flow region formed in the bulge of the aneurysm, where increased particle residence time and velocities lower than 2.5 cm/s were computed. The region of slow flow was found to have filled with thrombus following surgery. Predictions of numerical. simulation methods are consistent with the observed outcome following surgical treatment of an aneurysm. The study demonstrates that computational models may provide hypotheses to test in future studies, and might offer guidance for the interventional treatment of cerebral aneurysms.