Neurodegenerative diseases: an overview of environmental risk factors.
Neurodegenerative diseases: an overview of environmental risk factors.
复制标题
DOI：
10.1289/ehp.7567
复制
发表时间：
2005-09
影响因子：
10.4
通讯作者：
Sonawane, Babasaheb R
中科院分区：
文献类型：
--
作者：
Brown, Rebecca C;Lockwood, Alan H;Sonawane, Babasaheb R
美国人口正在老龄化，越来越多的美国人患有神经退行性疾病。由于许多这些疾病的发病机制仍然未知，我们必须考虑到环境因素可能发挥因果作用。本文综述了阿尔茨海默病、帕金森病、帕金森综合征（多系统萎缩和进行性核上性麻痹）和肌萎缩侧索硬化症等神经退行性疾病的环境病因学流行病学证据。关于环境因素暴露与神经变性疾病之间的联系的流行病学证据尚不确定。然而，有迹象表明可能存在因果联系，显然需要进行更多的研究。
The population of the United States is aging, and an ever-increasing number of Americans are afflicted with neurodegenerative diseases. Because the pathogenesis of many of these diseases remains unknown, we must consider that environmental factors may play a causal role. This review provides an overview of the epidemiologic evidence for environmental etiologies for neurodegenerative diseases such as Alzheimer disease, Parkinson disease, parkinsonian syndromes (multiple system atrophy and progressive supranuclear palsy), and amyotrophic lateral sclerosis. Epidemiologic evidence for an association between environmental agents’ exposure and neurodegenerative diseases is not conclusive. However, there are indications that there may be causal links, and the need for more research is obvious.