Inter-organ protein and carbohydrate metabolic relationships during sepsis: necessary evils or uncanny coincidences?
Inter-organ protein and carbohydrate metabolic relationships during sepsis: necessary evils or uncanny coincidences?
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脓毒症期间器官间蛋白质和碳水化合物代谢关系：必然之恶还是不可思议的巧合？
DOI：
10.1097/00075197-199905000-00007
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Vary,TC
中科院分区：
文献类型：
--
作者：
Vary,TC
脓毒症改变了骨骼肌和肝脏之间代谢底物的动态通量。脓毒症引起的骨骼肌葡萄糖代谢紊乱在一定程度上决定了肝脏糖异生的速率。相比之下，加速的再生速率不驱动骨骼肌中的净catalysts，脓毒症或炎症中肝蛋白代谢的上调似乎也不取决于或依赖于脓毒症期间肌肉蛋白的catalysts。
Sepsis alters the dynamic flux of metabolic substrates between skeletal muscle and liver. Derangements in skeletal muscle glucose metabolism evoked by sepsis to a certain extent determine the rate of gluconeogenesis in the liver. In contrast, accelerated rates of gluconeogenesis do not drive net catabolism in skeletal muscle, nor does the upregulation of hepatic protein metabolism in sepsis or inflammation appear to be contingent or dependent upon the catabolism of muscle proteins during sepsis.