Characterisation of five novel zebrafish Eph-related receptor tyrosine kinases suggests roles in patterning the neural plate
Characterisation of five novel zebrafish Eph-related receptor tyrosine kinases suggests roles in patterning the neural plate
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DOI：
10.1007/s004270050082
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发表时间：
1997-04-01
影响因子：
2.4
通讯作者：
Holder, N
中科院分区：
文献类型：
--
作者：
Cooke, JE;Xu, QL;Holder, N
Eph相关受体酪氨酸激酶（RTK）是已知的最大的RTK亚家族，包括至少十几个成员。表达研究表明这些基因在神经系统、神经嵴、发育肢体和体节的模式化和分化中的作用。最近分离的一些Eph相关RTK配体家族已被证明在视网膜顶盖系统中起位置标识符的作用。我们以前的特点是三个Eph相关的RTK在斑马鱼（rtk 1 -3）。在这里，我们报告了5个新的斑马鱼Eph相关的RTK（rtk 4，rtk 5，rtk 6，rtk 7和rtk 8）的鉴定和描述其动态表达模式。基于这些表达模式，我们提出，rtk 4 -8发挥各种作用，建立领土内的发展中枢神经系统（CNS），并在随后的分化定义的神经元群体。
Eph-related receptor tyrosine kinases (RTKs) are the largest known subfamily of RTKs, comprising at least a dozen members. Expression studies suggest roles for these genes in patterning and differentiation of the nervous system, the neural crest, developing limbs and somites. Some of the recently isolated family of ligands for Eph-related RTKs have been shown to function as positional identifiers in the retinotectal system. We have previously characterised three Eph-related RTKs in the zebrafish (rtk1-3). Here we report the identification of five new zebrafish Eph-related RTKs (rtk4, rtk5, rtk6, rtk7 and rtk8) and describe their dynamic expression patterns. Based on these expression patterns, we propose that rtk4-8 play various roles in establishing territories within the developing central nervous system (CNS) and in the subsequent differentiation of defined neuronal populations.