Xrx1, a novel Xenopus homeobox gene expressed during eye and pineal gland development
Xrx1, a novel Xenopus homeobox gene expressed during eye and pineal gland development
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DOI：
10.1016/s0925-4773(96)00640-5
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发表时间：
1997-01-01
影响因子：
2.6
通讯作者：
Barsacchi, G
中科院分区：
文献类型：
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作者：
Casarosa, S;Andreazzoli, M;Barsacchi, G
我们已经分离出一个新的爪蟾同源盒基因Xrx 1，属于同源盒基因的配对类。Xrx 1在前神经板中表达，随后在发育中的眼睛的神经结构（神经视网膜和色素上皮）中表达，并且在源自前神经板的其他前脑结构中表达：在松果体中，在其整个发育过程中，在间脑底和垂体中。其表达的吻侧极限对应于交叉脊，一些作者认为这是神经管的最前极限：因此，Xrx 1可能代表迄今报道的最前表达的同源异型盒基因之一。此外，它在与昼夜节律的建立有关的器官中的表达可能表明Xrx 1在该功能的遗传控制中起作用。最后，Xrx 1的表达在胚胎进行各种治疗，或显微注射不同的dorsalizing剂（头蛋白，Xwnt-8）的分析表明，垂直诱导信号导致头部形态需要激活Xrx 1。(C)1997 Elsevier Science爱尔兰有限公司
We have isolated st novel Xenopus homeobox gene, Xrx1, belonging to the paired-like class of homeobox genes. Xrx1 is expressed in the anterior neural plate, and subsequently in the neural structures of the developing eye (neural retina and pigmented epithelium), and in other forebrain structures deriving from the anterior neural plate: in the pineal gland, throughout its development, in the diencephalon floor and in the hypophysis. Its rostral limit of expression corresponds to the chiasmatic ridge, which some authors consider as the anteriormost Limit of the neural tube: thus, Xrx1 may represent one of the most anteriorly expressed homeobox genes reported to date. Moreover, its expression in organs implicated in the establishment of circadian rhythms, may suggest for Xrx1 a role in the genetic control of this function. Finally, analysis of Xrx1 expression in embryos subjected to various treatments, or microinjected with different dorsalizing agents (noggin, Xwnt-8), suggests that vertical inductive signals leading to head morphogenesis are required to activate Xrx1. (C) 1997 Elsevier Science Ireland Ltd.