Early-life factors and endometriosis risk.
Early-life factors and endometriosis risk.
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DOI：
10.1016/j.fertnstert.2015.06.040
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发表时间：
2015-10
影响因子：
6.7
通讯作者：
Holt VL
中科院分区：
文献类型：
--
作者：
Upson K;Sathyanarayana S;Scholes D;Holt VL
研究与成年期子宫内膜异位症风险相关的早期生活因素。基于人群的病例对照研究。在华盛顿州西部的一个大型综合医疗保健系统中，对18-49岁的女性登记者进行了妇女子宫内膜异位症风险（WREN）研究。病例组（n=310）为1996-2001年间首次诊断为子宫内膜异位症的女性，对照组（n=727）为从医疗保健系统人群中随机选择的未诊断为子宫内膜异位症的女性。没有。宫内己烯雌酚（DES）暴露、母亲吸烟、母亲分娩年龄、头胎状况、出生体重、胎儿数量、早产和婴儿期定期大豆配方奶粉喂养与子宫内膜异位症之间关系的调整后优势比（aOR）和95%置信区间（CI）使用无条件逻辑回归估计，调整频率匹配和混杂变量。通过面对面访谈，回顾性地确定了有关早期生活因素的信息，并直接从参与者的母亲或其他家庭成员那里收集了有关母亲使用DES和定期喂养大豆配方奶粉的信息。我们观察到，在婴儿时期经常喂食大豆配方奶粉的女性患子宫内膜异位症的风险是未接触大豆配方奶粉的女性的两倍多（aOR 2.4，95%CI：1.2-4.9）。我们的数据还表明，早产（aOR 1.7，95% CI：0.9-3.1）和母体使用DES（OR 2.0，95% CI：0.8-4.9，仅调整频率匹配变量）会增加子宫内膜异位症的风险，尽管这些置信区间包括空值。我们的研究结果支持这一假设，即胎儿和婴儿期发育的中断可能会增加成年期子宫内膜异位症的风险。
To study early-life factors in relation to endometriosis risk in adulthood. Population-based case-control study. Women’s Risk of Endometriosis (WREN) study was conducted among female enrollees ages 18-49 years of a large, integrated healthcare system in western Washington State. Cases (n=310) were women diagnosed for the first time with endometriosis between years 1996-2001 and controls (n=727) were women without a diagnosis of endometriosis randomly selected from the healthcare system population. None. Adjusted odds ratios (aOR) and 95% confidence intervals (CI) for the associations between intrauterine diethylstilbestrol (DES) exposure, maternal smoking, mother’s age at delivery, firstborn status, birth weight, fetal number, prematurity, and regular soy formula feeding during infancy and endometriosis were estimated using unconditional logistic regression, adjusting for frequency matching and confounding variables. Information on early-life factors was ascertained retrospectively by in-person interview, with information on maternal DES use and regular soy formula feeding directly gathered from the participant’s mother or other family member. We observed that women who were regularly fed soy formula as infants had over twice the risk of endometriosis compared to unexposed women (aOR 2.4, 95% CI: 1.2-4.9). Our data also suggested increased endometriosis risk with prematurity (aOR 1.7, 95% CI: 0.9-3.1) and maternal use of DES (OR 2.0, 95% CI: 0.8-4.9, adjusting only for frequency matching variables), although these confidence intervals included the null. Our results support the hypothesis that disruption of development during fetal and infant periods may increase the risk of endometriosis in adulthood.