The Multiple Organ Dysfunction Score (MODS) versus the Sequential Organ Failure Assessment (SOFA) score in outcome prediction
The Multiple Organ Dysfunction Score (MODS) versus the Sequential Organ Failure Assessment (SOFA) score in outcome prediction
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DOI：
10.1007/s00134-002-1491-3
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发表时间：
2002-11-01
影响因子：
38.9
通讯作者：
Vincent, JL
中科院分区：
文献类型：
--
作者：
Bota, DP;Melot, C;Vincent, JL
目的：比较使用多器官功能障碍评分 (MODS) 和序贯器官衰竭评估 (SOFA) 的结果预测，这是重症监护病房 (ICU) 中最常用于评估器官功能障碍的两个系统。设计：前瞻性、观察性研究。环境：大学医院 ICU，有 31 个床位。患者和参与者：949 名 ICU 患者。测量和结果：MODS 和 SOFA 评分在入院时计算，每 48 小时计算一次，直至出 ICU。入院时计算急性生理学和慢性健康评估 (APACHE) II 评分。接受者操作特征 (AUROC) 曲线下面积用于比较初始、48 小时、96 小时、最大和最终分数。 949 名患者中，277 人死亡（死亡率 29.1%）。 329 名患者出现休克（死亡率 55.3%）。在死亡率预测方面，两个分数之间没有显着差异。所有患者的 APACHE II 评分结果预测与初始 MODS 和 SOFA 评分相似，休克患者的结果预测稍差。使用分数的心血管成分 (CV)，SOFA 分数在所有时间间隔的结果预测都更好（初始 AUROC SOFA CV 0.750 与 MODS CV 0.694，p
Objective: To compare outcome prediction using the Multiple Organ Dysfunction Score (MODS) and the Sequential Organ Failure Assessment (SOFA), two of the systems most commonly used to evaluate organ dysfunction in the intensive care unit (ICU). Design: Prospective, observational study. Setting: Thirty-one-bed, university hospital ICU. Patients and participants: Nine hundred forty-nine ICU patients. Measurements and results: The MODS and the SOFA score were calculated on admission and every 48 h until ICU discharge. The Acute Physiology and Chronic Health Evaluation (APACHE) II score was calculated on admission. Areas under receiver operating characteristics (AUROC) curves were used to compare initial, 48 h, 96 h, maximum and final scores. Of the 949 patients, 277 died (mortality rate 29.1%). Shock was observed in 329 patients (mortality rate 55.3%). There were no significant differences between the two scores in terms of mortality prediction. Outcome prediction of the APACHE II score was similar to the initial MODS and SOFA score in all patients, and slightly worse in patients with shock. Using the scores' cardiovascular components (CV), outcome prediction was better for the SOFA score at all time intervals (initial AUROC SOFA CV 0.750 vs MODS CV 0.694, p