Abnormal plastic phenomena of sensory-precipitated epilepsy in the mutant El mouse
Abnormal plastic phenomena of sensory-precipitated epilepsy in the mutant El mouse
复制标题
突变El小鼠感觉诱发性癫痫的异常可塑性现象
DOI：
10.1016/0014-4886(82)90172-8
复制
发表时间：
1982
影响因子：
5.3
通讯作者：
Y. Nakamoto
中科院分区：
文献类型：
--
作者：
J. Suzuki;Y. Nakamoto
通过长期临床观察和脑电图记录，研究了El小鼠（一种易患癫痫的近交突变株）癫痫发作的发生过程。观察到先前发作的消退、强化和后效现象。通过重复的自然感官刺激，包括观察和投掷程序，诱发El小鼠的癫痫发作。随着刺激的重复，癫痫发作阈值降低，癫痫发作的发生率升高，达到100%。在小鼠最初暴露于刺激后几周，临床表现以流产形式开始，并以典型的全身抽搐和狂奔结束。阵发性放电在脑电图中表现为孤立的尖峰，首先来自受限的顶叶区域；随后，脉冲和波的复合体扩展到大脑的广大区域。即使在间歇期，在最易发作的El小鼠的脑电图中有时也能看到孤立的尖峰。在长时间不刺激后，阈值升高，或者在癫痫完全发作的小鼠中观察到癫痫发作消失。强化刺激是El小鼠持续发作的必要条件。在癫痫发作恢复期间，其发生率比前发育时期增加得更快。总的来说，El小鼠癫痫发作可能是一种异常的可塑性现象，除了遗传易感性和个体发育外，还与重复的感觉刺激有关。
The processes of development of seizures of the El mouse, an inbred mutant strain susceptible to epilepsy, were investigated by long-term clinical observations and EEG recordings. The phenomena of extinction, reinforcement, and an aftereffect of the antecedent occurrence of seizures were observed. Seizures of El mice were elicited by repetition of natural sensory stimulation, which consisted of observation and tossing procedures. The seizure thresholds were lowered with a repetition of stimuli, and the incidence of seizures became higher, attaining 100%. Clinical manifestations started with abortive forms several weeks after the mice were initially exposed to stimulation, and concluded with typical general convulsions and wild running. Paroxysmal discharges appeared in the EEG as isolated spikes, first from restricted parietal areas; subsequently spike and wave complexes were extedded over wide areas of the brain. Even during the interictal period isolated spikes sometimes could be seen in the EEGs of the El mice most susceptible to seizures. After a long period without stimulation, the thresholds were raised, or extinction of seizures was observed in mice with fully developed seizures. Reinforcement stimulation was necessary for seizures of El mice to occur constantly. During recovery of the occurrence of seizures, their incidence increased sooner than in the previous developmental period. In general, the El mouse seizure might represent an abnormal plastic phenomenon associated with repetition of sensory stimuli in addition to genetic predisposition and ontogenetic development.