Neural signatures of semantic and phonemic fluency in young and old adults.
Neural signatures of semantic and phonemic fluency in young and old adults.
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DOI：
10.1162/jocn.2009.21219
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发表时间：
2009-10
影响因子：
3.2
通讯作者：
Crosson B
中科院分区：
文献类型：
--
作者：
Meinzer M;Flaisch T;Wilser L;Eulitz C;Rockstroh B;Conway T;Gonzalez-Rothi L;Crosson B
随着年龄的增长，我们选择和产生单词的能力会发生变化，但我们对老年人单词查找困难的潜在神经基础知之甚少。本研究的目的是阐明特定的额叶介导的检索过程中涉及的单词查找困难与先进的年龄的变化。我们实施了两个明显的口头（语义和音素）流畅性任务，在功能磁共振成像和比较老年人和年轻人的大脑活动模式。在音素任务的性能是可比的两个年龄组和反映强烈的左侧（额叶）活动模式。另一方面，一个显着下降的表现在语义任务中的老年组伴随着额外的右（下和中）额叶活动，这是负相关的性能。此外，年轻组在两个流畅性任务中都使用了左额下回的不同部分，而老年组则没有表现出这种区别。因此，功能的完整性和有效的招聘左额叶语言区似乎是关键的成功词检索在老年。
As we age, our ability to select and produce words changes, yet we know little about the underlying neural substrate of word-finding difficulties in old adults. The present study was designed to elucidate changes in specific frontally mediated retrieval processes involved in word-finding difficulties associated with advanced age. We implemented two overt verbal (semantic and phonemic) fluency tasks during functional magnetic resonance imaging and compared brain activity patterns of old and young adults. Performance during the phonemic task was comparable for both age-groups and mirrored by strongly left lateralized (frontal) activity patterns. On the other hand, a significant drop of performance during the semantic task in the older goup was accompanied by additional right (inferior and middle) frontal activity, which was negatively correlated with performance. Moreover, the younger group recruited different subportions of the left inferior frontal gyrus for both fluency tasks, while the older participants failed to show this distinction. Thus, functional integrity and efficient recruitment of left frontal language areas seems to be critical for successful word-retrieval in old age.
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