The role of Zn2+ in shaping intracellular Ca2+ dynamics in the heart.
The role of Zn2+ in shaping intracellular Ca2+ dynamics in the heart.
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DOI：
10.1085/jgp.202213206
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发表时间：
2023-07-03
影响因子：
3.8
通讯作者：
Pitt, Samantha J.
中科院分区：
文献类型：
--
作者：
Dorward, Amy M.;Stewart, Alan J.;Pitt, Samantha J.
在这篇综述中，我们讨论了Zn2+和锌转运体在心肌细胞Ca2+动力学调节中的作用。越来越多的证据表明，Zn2+作为第二信使，能够将细胞外刺激转化为细胞内信号转导事件。Zn2+作为一种信号分子在心血管功能中的重要性越来越受到关注。在心脏中，Zn2+在兴奋-收缩（EC）偶联、兴奋-转录偶联和心室形态发生中起重要作用。心脏组织中的Zn2+稳态是通过转运体、缓冲液和传感器的联合作用而受到严格调节的。Zn2+处理不当是各种心血管疾病的共同特征。然而，控制Zn2+细胞内分布及其在正常心功能和病理状态下变化的确切机制尚不完全清楚。在这篇综述中，我们考虑了心脏细胞内Zn2+浓度调节的主要途径，Zn2+在EC偶联中的作用，并讨论了由Zn2+调节蛋白表达水平和功效改变引起的Zn2+失衡是心功能障碍进展的关键驱动因素。
In this review, we discuss the role of Zn2+ and zinc transporters in regulating cellular Ca2+ dynamics in cardiac muscle. Increasing evidence suggests that Zn2+ acts as a second messenger capable of transducing extracellular stimuli into intracellular signaling events. The importance of Zn2+ as a signaling molecule in cardiovascular functioning is gaining traction. In the heart, Zn2+ plays important roles in excitation–contraction (EC) coupling, excitation–transcription coupling, and cardiac ventricular morphogenesis. Zn2+ homeostasis in cardiac tissue is tightly regulated through the action of a combination of transporters, buffers, and sensors. Zn2+ mishandling is a common feature of various cardiovascular diseases. However, the precise mechanisms controlling the intracellular distribution of Zn2+ and its variations during normal cardiac function and during pathological conditions are not fully understood. In this review, we consider the major pathways by which the concentration of intracellular Zn2+ is regulated in the heart, the role of Zn2+ in EC coupling, and discuss how Zn2+ dyshomeostasis resulting from altered expression levels and efficacy of Zn2+ regulatory proteins are key drivers in the progression of cardiac dysfunction.
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影响因子：
16
作者：
Cho, Hyo Min;Ryu, Jae Ryun;Sun, Woong
通讯作者：
Sun, Woong
影响因子：
3.7
作者：
Diaz-Sylvester PL;Porta M;Copello JA
通讯作者：
Copello JA
影响因子：
1.5
作者：
Andrews, GK;Wang, HB;Palmiter, RD
通讯作者：
Palmiter, RD
DOI：
10.1016/0006-291x(83)90681-2
发表时间：
1983-01-01
影响因子：
3.1
作者：
BAUDIER, J;HAGLID, K;GERARD, D
通讯作者：
GERARD, D
影响因子：
4.8
作者：
Bhanumathy, Cunnigaiper;da Fonseca, Paula C. A.;Joseph, Suresh K.
通讯作者：
Joseph, Suresh K.