Chemical Composition and Nutraceutical Potential of Indian Borage (Plectranthus amboinicus) Stem Extract
Chemical Composition and Nutraceutical Potential of Indian Borage (Plectranthus amboinicus) Stem Extract
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DOI：
10.1155/2013/320329
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发表时间：
2013-01-01
影响因子：
3
通讯作者：
Varadaraj, Mandyam Chakravarthy
中科院分区：
文献类型：
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作者：
Bhatt, Praveena;Joseph, Gilbert Stanley;Varadaraj, Mandyam Chakravarthy
通过DPPH自由基清除、还原力测定、超氧阴离子自由基清除和总抗氧化能力等体外实验，研究了印度琉璃苣（Plectanthus amboinicus）茎的抗氧化活性。该提取物还表现出抗血小板聚集能力、抗菌活性和对癌细胞系Caco-2、HCT-15和MCF-7的抗增殖作用。提取物的植物化学评价揭示了总酚（49.91mg GAE/g提取物）、总黄酮（26.6mg RE/g提取物）和缩合单宁（0.7mg TAE/g提取物）的存在。在主要酚类物质中，迷迭香酸（6.160mg/g提取物）占主导地位，其次是咖啡酸（0.770mg/g提取物）、芦丁（0.324mg/g提取物）、没食子酸（0.260mg/g提取物）、槲皮素（0.15mg/g提取物）和对香豆酸（0.104mg/g提取物）。茎的甲醇提取物具有明显的生物活性和生物分子的存在，表明其作为功能性食品成分和营养保健品的潜在应用。
The stem of Indian borage (Plectranthus amboinicus) was found to be an antioxidant rich fraction as evaluated by in vitro models such as DPPH free radical scavenging, reducing power assay, superoxide anion radical scavenging, and total antioxidant capacity. The extract also exhibited antiplatelet aggregation ability, antibacterial activity, and antiproliferative effect against cancer cell lines: Caco-2, HCT-15, and MCF-7. Phytochemical evaluation of the extract revealed the occurrence of total phenolics (49.91mg GAE/g extract), total flavonoids (26.6mg RE/g extract), and condensed tannins (0.7mg TAE/g extract). Among the major phenolics, rosmarinic acid (6.160mg/g extract) was predominant, followed by caffeic acid (0.770mg/g extract), rutin (0.324mg/g extract), gallic acid (0.260mg/g extract), quercetin (0.15mg/g extract), and p-coumaric acid (0.104mg/g extract). The appreciable biological activity and presence of biomolecules in the methanolic extract of stem indicate its potential application as functional food ingredients and nutraceuticals.