Cardiovascular Effects of Exercise Training Molecular Mechanisms
Cardiovascular Effects of Exercise Training Molecular Mechanisms
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DOI：
10.1161/circulationaha.110.939959
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发表时间：
2010-09-21
期刊：
影响因子：
37.8
通讯作者：
Adams, Volker
中科院分区：
文献类型：
--
作者：
Gielen, Stephan;Schuler, Gerhard;Adams, Volker
在我们祖先的自然栖息地，体育活动不是预防性干预，而是生存问题。在这个食物稀缺、危险无处不在的恶劣环境中，人类基因被选择用来优化有氧代谢途径，并为未来潜在的饥荒保存能量。1心脏和血管功能不断受到间歇性高强度体力活动的挑战，并适应在这些条件下工作的骨骼肌的代谢需求。当谈到运动对心血管的分子效应时，我们应该记住，大多数从基线的变化可能是恢复正常值。在西方社会，体育活动的统计平均值远远低于我们遗传背景的正常水平，久坐不动的生活方式加上过量的食物摄入已经超过吸烟，成为美国第一大可预防的死亡原因。2
In the natural habitat of our ancestors, physical activity was not a preventive intervention but a matter of survival. In this hostile environment with scarce food and ubiquitous dangers, human genes were selected to optimize aerobic metabolic pathways and conserve energy for potential future famines. 1 Cardiac and vascular functions were continuously challenged by intermittent bouts of high-intensity physical activity and adapted to meet the metabolic demands of the working skeletal muscle under these conditions.When speaking about molecular cardiovascular effects of exercise, we should keep in mind that most of the changes from baseline are probably a return to normal values. The statistical average of physical activity in Western societies is so much below the levels normal for our genetic background that sedentary lifestyle in combination with excess food intake has surpassed smoking as the No. 1 preventable cause of death in the United States. 2